# US 2016/0354418 A1 · Use of compositions comprising bifidobacterium animalis ssp. lactis lmg p-28149

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- Number: US 2016/0354418 A1
- Document ID: US20160354418A1
- Status: Published application
- Kind: A1
- Application number: 15/118,077
- Filed: 2015-02-13
- Published: 2016-12-08
- Earliest claimed: 2014-02-14
- Assignees: Vesale Pharma SA
- Applicants: Vesale Pharma SA
- Inventors: Johan Quintens; Jehan Lienart van Lidth de Jeude; Corinne Grangette; Bruno Pot; Kassem Makki; Isabelle Wolowczuk; Jeanne Alard; Véronique Lehrter-Valenti
- Web page: https://patentgrep.com/patent/US20160354418A1

## CPC

- A61K 35/745: Bifidobacteria
- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61K 8/9728: Fungi, e.g. yeasts
- A61K 8/99: from microorganisms other than algae or fungi, e.g. protozoa or bacteria
- A61K 9/4891: {Coated capsules; Multilayered drug free capsule shells (with drug coating for immediate release A61K9/4808; osmotic devices A61K9/0004)}
- A61K 35/741: Probiotics (probiotic yeast, e.g. saccharomyces A61K36/06)
- A61K 36/06: Fungi, e.g. yeasts
- A61P 3/04: Anorexiants; Antiobesity agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 19/06: for countering cellulitis
- C12N 1/20: Bacteria; Culture media therefor
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A23V 2400/515: Animalis
- A61K 2800/85: Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A composition made from at least one probiotic for the use of same in the curative treatment of body weight gain in an overweight human and/or in the preventive treatment of body weight gain in a human who is overweight or has been overweight, said probiotic being Bifidobacterium animalis ssp. Iactis n° LMG P-28149.

## Claims

### Claim 1

A composition based on at least one probiotic for its use in the curative treatment of body weight gain in overweight human beings and/or in the preventive treatment of body weight gain in overweight human beings or having been overweight, characterized in that said probiotic is Bifidobacterium animalis ssp. lactis no. LMG P-28149.

### Claim 2 (depends on 1)

The composition according to claim 1, comprising at least one additional probiotic selected from the group consisting of the following probiotics: Archaea, Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Verrucomicrobia, Fusobacteria, Metanobacteria, Spirochaetes, Fibrobacters, Deferribacteres, Deinococcus, Thermus, Cyanobacteria, Methanobrevibacterium, Lactobacillus, Peptostreptococcus, Ruminococcus, Coprococcus, Subdolingranulum, Dorea, Bulleidia, Anaerofustis, Gemella, Roseburia, Catenibacterium, Dialister, Anaerotruncus, Staphylococcus, Micrococcus, Propionibacterium, Enterobacteriaceae (non-pathogenic), Faecalibacterium, Bacteroides, Parabacteroides, Prevotella, Eubacterium, Akkermansia, Bacillus, Butyrivibrio, and Clostridium, or a combination thereof.

### Claim 3 (depends on 1)

The composition according to claim 1, comprising a fungus and/or yeast strain selected from the group consisting of Saccharomyces, Candida, Pichia, Debaryomyces, Torulopsis, Aspergillus, Rhizopus, Mucor, and Penicillium.

### Claim 4 (depends on 1)

The composition according to claim 1, wherein said Bifidobacterium animalis ssp. lactis no. LMG P-28149 and optionally said at least one additional probiotic are encapsulated in an encapsulation carrier.

### Claim 5 (depends on 4)

The composition according to claim 4, wherein said encapsulation carrier comprises at least one substance selected from the group consisting of alginate, chitosan, pectin, pullulan, gelatin, carrageenan, agar gel, or a combination thereof.

### Claim 6 (depends on 1)

The composition according to claim 1, comprising at least one source of food selected from the group consisting of a monosaccharide, polysaccharide, amino acid, peptide, protein, vitamin, yeast extract, halide salt of an alkaline or earth-alkaline metal, antioxidant, glycerol, zinc acetate, zinc chloride, zinc lactate, ascorbic acid, citric acid, plant oil, milk fat or a combination thereof.

### Claim 7 (depends on 1)

The composition according to claim 1, further comprising at least one prebiotic, thus forming a symbiotic composition.

### Claim 8 (depends on 1)

The composition according to claim 1, comprising a first enteric coating covering said Bifidobacterium animalis ssp. lactis no. LMG P-28149 and optionally said at least one additional probiotic.

### Claim 9 (depends on 8)

The composition according to claim 8, wherein said first enteric coating is selected from the group consisting of ethylcellulose, hydroxypropylcellulose, carboxymethylcellulose, Eudragit®, or a combination thereof.

### Claim 10 (depends on 1)

The composition according to claim 1, comprising a second external coating selected from the group consisting of alginate, chitosan, pectin, pullulan, gelatin, carrageenan, agar gel, cellulose, hemicellulose, ethyl cellulose, carboxymethyl cellulose, or a combination thereof.

### Claim 11 (depends on 1)

The composition according to claim 1, further comprising one or several biocompatible excipients.

### Claim 12

The non-therapeutic cosmetic use of a composition comprising at least a probiotic, in overweight human beings or having been overweight, said probiotic being Bifidobacterium animalis ssp. lactis no. LMG P-28149.

### Claim 13 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, said composition comprising at least one additional probiotic selected from the group consisting of the following probiotics: Archaea, Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Verrucomicrobia, Fusobacteria, Metanobacteria, Spirochaetes, Fibrobacters, Deferribacteres, Deinococcus, Thermus, Cyanobacteria, Methanobrevibacterium, Lactobacillus, Peptostreptococcus, Ruminococcus, Coprococcus, Subdolingranulum, Dorea, Bulleidia, Anaerofustis, Gemella, Roseburia, Catenibacterium, Dialister, Anaerotruncus, Staphylococcus, Micrococcus, Propionibacterium, Enterobacteriaceae (non-pathogenic), Faecalibacterium, Bacteroides, Parabacteroides, Prevotella, Eubacterium, Akkermansia, Bacillus, Butyrivibrio, and Clostridium, or a combination thereof.

### Claim 14 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, said composition comprising a fungus and/or yeast strain selected from the group consisting of Saccharomyces, Candida, Pichia, Debaryomyces, Torulopsis, Aspergillus, Rhizopus, Mucor, and Penicillium.

### Claim 15 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, wherein said Bifidobacterium animalis ssp. lactis no. LMG P-28149 and optionally said at least one additional probiotic are encapsulated in an encapsulation carrier.

### Claim 16 (depends on 15)

The non-therapeutic cosmetic use of a composition according to claim 15, wherein said encapsulation carrier comprises at least one substance selected from the group consisting of alginate, chitosan, pectin, pullulan, gelatin, carrageenan, agar gel,. or a combination thereof.

### Claim 17 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, said composition comprising at least one food source selected from the group consisting of a monosaccharide, polysaccharide, amino acid, peptide, protein, vitamin, yeast extract, halide salt of an alkaline or earth-alkaline metal, antioxidant, glycerol, zinc acetate, zinc chloride, zinc lactate, ascorbic acid, citric acid, plant oil, milk fat, or a combination thereof.

### Claim 18 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, said composition further comprising at least one prebiotic, thus forming a symbiotic composition.

### Claim 19 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, said composition comprising a first enteric coating covering said Bifidobacterium animalis ssp. lactis no. LMG P-28149 and optionally said at least one additional probiotic.

### Claim 20 (depends on 19)

The non-therapeutic cosmetic use of a composition according to claim 19, wherein said first enteric coating is selected from the group consisting of ethyl cellulose, hydroxypropyl cellulose, carboxymethylcellulose, Eudragit®, or a combination thereof.

### Claim 21 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, said composition comprising a second external coating selected from the group consisting of alginate, chitosan, pectin, pullulan, gelatin, carrageenan, agar gel, cellulose, hemicellulose, ethylcellulose, carboxymethylcellulose, or a combination thereof.

### Claim 22 (depends on 12)

The non-therapeutic cosmetic use of a composition according to claim 12, said composition further comprising one or several biocompatible excipients.

### Claim 23

A culture medium for the probiotic Bifidobacterium animalis ssp. lactis no. LMG P-28149 comprising at least one source of protein and at least one source of carbohydrates, said culture medium being characterized in that it further comprises glutathion.

### Claim 24 (depends on 23)

The culture medium according to claim 23, characterized in that glutathion is present in a concentration comprised between 20 and 30 g/l of culture medium.

### Claim 25 (depends on 23)

The culture medium according to claim 23, characterized in that said source of carbohydrates comprises at least one sugar or a mixture of sugars, which are selected from the group consisting of lactose, glucose, galactose, fructose, maltodextrin, starch, trehalose, maltotriose, and a combination thereof.

### Claim 26 (depends on 23)

The culture medium according to claim 23, characterized in that it further comprises at least one aminoacid, for example, glucosamine or galactosamine.

### Claim 27 (depends on 23)

The culture medium according to claim 23, characterized in that it further comprises at least one yeast extract.

### Claim 28 (depends on 23)

A method for producing by fermentation the probiotic Bifidobacterium animalis ssp. lactis no. LMG P-28149, said method comprising at least one step for cultivating said probiotic in a culture medium according to claim 23.