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AssigneeAlbert Einstein College of Medicine
InventorsJoel FRIEDMAN, Navati MAHANTESH
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Described herein is a method of making modified paramagnetic nanoparticles with improved therapeutic loading efficiency and enhanced circulation properties. The method comprises coating a paramagnetic nanoparticle (PMNP) with a hydrophobic coating comprising lipophilic drug and a polymer. Also described herein is a PMNP, and a composition comprising PMNP. In certain embodiment, the PMNP have improved permeability through the blood brain barrier. Also described herein is a method of using the PMNP for the treatment of diseases. In certain embodiments, the method of treatment is a combination therapy. Described herein are imaging of therapeutic delivery of PMNP and diagnostic methods using the PMNP. Also described herein is a diagnostic kit that comprises the PMNP. The invention provides compositions comprising a paramagnetic nanoparticle having an external coating comprising a small organic molecule, a polymer, a blood protein, oleic acid, a lipophilic pharmaceutical or an allosteric effector of hemoglobin, as well as methods of making thereof, and use thereof in treatment and imaging.
A method of making modified PMNP comprising the steps of:
A method of making a modified PMNP comprising the steps of:
A method of making a drug-loaded albumin-coated paramagnetic nanoparticle (alb-PMNP) comprising the steps of:
A method of making modified PMNP comprising the steps of:
A modified paramagnetic nanoparticle (PMNP) comprising a PMNP core, which core comprises a coating, said coating comprising oleic acid, a fatty acid, albumin, or a combination thereof, said coating is dispersed therewith an allosteric effector of hemoglobin, curcumin, melanin, siRNA, plasmids, nitro fatty acids, adriamycin, taxol, or a combination thereof and wherein polymer PEG-DSPE are attached to the PMNP core.
Dependencies are inferred from the claim text.