Medicament and method for treating innate immune response diseases
AssigneeDsm IP Assets B.V.
InventorsMaaike Johanna BRUINS, Luppo EDENS, Lenneke NAN
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AssigneeDsm IP Assets B.V.
InventorsMaaike Johanna BRUINS, Luppo EDENS, Lenneke NAN
Estimating the term…
This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.
A dietary supplement or a pharmaceutical composition comprising the Aspergillus niger aspergilloglutamic peptidase, a prolyl-endopeptidase, and pharmaceutically or dietary acceptable excipients.
A dietary supplement or a pharmaceutical composition comprising the Aspergillus niger aspergilloglutamic peptidase for use as a medicament.
Method for degrading plant allergens in a food composition comprising, incubating a food composition containing plant allergens with Aspergillus niger aspergilloglutamic peptidase, for a time sufficient to hydrolyze plant allergens.
A foodstuff prepared by first incubating a food product containing plant allergens with Aspergillus niger aspergilloglutamic peptidase, for a time sufficient to hydrolyze plant allergens, said foodstuff comprising degraded alpha-amylase/trypsin inhibitors.
A baking composition or a dough comprising the Aspergillus niger aspergilloglutamic peptidase, and a prolyl-endopeptidase.
A method to prepare a dough comprising the step of adding an Aspergillus niger aspergilloglutamic peptidase to at least one dough ingredient.
An enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and at least one additional enzyme.
Dependencies are inferred from the claim text.