Actin binding peptides and compositions comprising same for inhibiting angiogenesis and treating medical conditions associated with same
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsOded SHOSEYOV, Betty SCHWARTZ, Shani DORON, Liron NESIEL, Assaf FRIEDLER, Hadar AMARTELY, Levava ROIZ, Patricia SMIRNOFF, Iris LEWIN
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Abstract
The present invention, in some embodiments thereof, relates to biologically active peptides and, more particularly, but not exclusively, to peptides from T2 RNase (RNASET2) having actin binding, pharmaceutical compositions comprising the same, therapeutic use thereof and methods for their production.
Claims35
An isolated peptide comprising a core amino acid sequence, which comprises at least 10 amino acids of helix 5 of human RNASET2, or naturally occurring homologues thereof, or conservative substitutions thereof, wherein the peptide is 23-50 amino acids in length and wherein the peptide binds actin.
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An isolated peptide comprising a core amino acid sequence, which comprises at least 5 amino acids of helix 5 of human RNASET2, or naturally occurring homologues thereof, or conservative substitutions thereof, wherein the peptide is 5-22 amino acids in length and wherein the peptide binds actin.
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Dependencies are inferred from the claim text.