Clostrubins

A compound of the general formula (I):

• or a pharmacologically acceptable salt thereof, wherein
• R1, R2, R3, R4 and R31 each independently represents H, OH, F, Cl, Br, I, NO2, CF3, CN, NH2, NO2, —(CH2)m—R;
• —C(═O)R;
• —C(═O)NHR;
• —NHC(═O)R;
• —NHSO2R;
• S(O)nX2;
• SO2NR5R6;
• or a group comprising a linear or branched polyethylene glycol (PEG) group which comprises the formula —(CH2—CH2—O)t— with t being an integer of from 2 to 100 and has a molecular weight (MW) of from 400 to 50000 Da;
• R represents H;
• —(CH2)p—X1;
• —(CH2)p—OX1;
• a C1-6 heteroalkyl;
• a cycloalkyl;
• a heterocycloalkyl;
• an alkylcycloalkyl;
• a heteroalkylcycloalkyl;
• an aryl;
• a heteroaryl;
• an aralkyl;
• or a heteroaralkyl group;
• R5 and R6 each independently represents a hydrogen atom;
• or —(CH2)m—R;
• or
• R5 and R6 are taken together to form a 5- to 8-membered saturated, unsaturated or aromatic heterocycle containing 1 to 4 N atoms or 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur, which heterocycle may be unsubstituted or mono- , di or trisubstituted by halogen atom or R;
• or R5 and R6 are taken together to form a 5- to 8-membered saturated, unsaturated or aromatic heterocycle containing 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur, which is fused to one or two rings selected from the group consisting of cycloalkyl;
• heterocycloalkyl;
• alkylcycloalkyl;
• heteroalkylcycloalkyl;
• aryl;
• heteroaryl;
• aralkyl;
• and heteroaralkyl;
• X1 represents a C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl group, in which 1 to 5 H atoms may, independently of each other, be replaced by halogen atom, CN, CF3, NO2, OR or NHR, and/or in which one or two non-adjacent CH2 group(s) may be replaced by O, NH, S, SO, SO2, or C3-7 cycloalkyl;
• X2 represents CN, CF3, —(CH2)p—X1, or NR5R6;
• m is 0, 1, 2 or 3;
• n is 0, 1 or 2;
• and
• p is an integer from 0 to 6.