Process for preparing antiviral compounds
AssigneeAbbVie Inc.
InventorsShashank Shekhar, Thaddeus S. Franczyk, David M. Barnes, Travis B. Dunn, Anthony R. Haight, Vincent S. Chan
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Abstract
This disclosure is directed to: (a) processes for preparing compounds and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compounds and salts; (c) pharmaceutical compositions comprising the compounds or salts; and (d) methods of use of such compositions.
Claims22
A compound of formula (4), or salt thereof:
- wherein R4 is selected from the group consisting of C1-C6-alkyl, C1-C6-fluoroalkyl, C1-C6-hydroxyalkyl, phenyl, 2-thienyl, 3-thienyl, 2-furanyl, and 3-furanyl;
- and
- R5 is selected from the group consisting of hydrogen, fluoro, chloro, C1-C6-alkyl, and C1-C6-alkyloxy.
A composition comprising 1-(3-tert-butyl-5-(6-hydroxynaphthalen-2-yl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione (compound (4)) and N-(6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide (compound (A-1)) or a salt thereof.
Dependencies are inferred from the claim text.