Means and methods for increasing antibiotic activity

A method for counteracting bacterial activity and/or growth, the method comprising exposing bacteria to:

• an antibiotic;
• and
• anthranilic acid, or a pharmaceutically acceptable salt, ester, hydrate, solvate or functional derivative thereof.

A method for treating a subject suffering from, or at risk of suffering from, a bacterial infection, the method comprising administering to the subject:

• an antibiotic;
• and
• anthranilic acid, or a pharmaceutically acceptable salt, ester, hydrate, solvate or functional derivative thereof.

A method of increasing the antibacterial activity of an antibiotic, the method comprising:

• utilizing anthranilic acid, or a pharmaceutically acceptable salt, ester, hydrate, solvate or functional derivative thereof, for increasing the antibacterial activity of an antibiotic.

A composition or kit of parts, comprising:

• anthranilic acid, or a pharmaceutically acceptable salt, ester, hydrate, solvate or functional derivative thereof;
• and
• an antibiotic in a unit dose that is at most half the amount required for killing bacteria in the absence of anthranilic acid or a pharmaceutically acceptable salt, ester, hydrate, solvate or functional derivative of anthranilic acid.

A method for culturing a micro-organism, the method comprising:

• culturing the micro-organism in the presence of a plant-derived compound;
• and
• determining whether the micro-organism produces a compound with antimicrobial activity and/or a compound that reduces the resistance of bacteria to an antibiotic.