Risk Assessment for Therapeutic Drugs
AssigneeConquerAb Inc.
InventorMaria D. F. S. Barbosa
Life of this patent
Estimating the term…
Abstract
Methods to estimate safety and/or efficacy of therapeutic drugs, which include portable devices for anti-drug antibody (ADA) testing and databases containing anonymized data from human and/or animal models and related analyses, are provided. These methods and compositions can be used in various applications, including but not restricted to the following: uniform testing of patients for ADA; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs marketed for a given disease and also gene therapy; scientific guidance for discovering and/or developing therapeutic drugs; postmarketing surveillance of therapeutic drugs.
Claims18
Methods and compositions for assessing risks associated with immune responses against therapeutic drugs (or lack thereof), comprising clinical (and/or nonclinical) data and analyses logistically organized in databases.
A portable device for testing anti-drug antibodies (ADAs) in tissues and body fluids, including but not restricted to blood, serum and plasma. That device can be constructed using the entire therapeutic drug, and/or using specific regions of the therapeutic drug or degradation products, including but not restricted to peptides and/or polyethylene glycol.
Dependencies are inferred from the claim text.