PREPARATION OF Ag18F AND ITS USE IN THE SYNTHESIS OF PET RADIOTRACERS
AssigneeThe Regents Ofthe University of Michigan
InventorsPeter J. H. Scott, Allen F. Brooks, Naoko Ichiishi, Melanie S. Sanford
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Abstract
Copper-catalyzed radiofluorination of aryl iodides using Ag18F, methods of preparing Ag18F, and compounds obtained by copper-catalyzed radiofluorination of aryl iodides using Ag18F are disclosed. Diagnostic and therapeutic methods involving such compounds also are disclosed.
Claims36
A method of preparing a radiolabeled aryl fluoride comprising:
- reacting an aryl iodide having a formula ArI with Ag18F in the presence of a copper source under conditions sufficient to form a radiolabeled aryl fluoride of Formula (1)
- wherein Ar is an aryl group.
A reaction mixture for radiofluorinating an aryl iodide precursor compound, the reaction mixture comprising an aryl iodide precursor compound having a formula ArI, Ag18F, and a copper source.
A method of preparing Ag18F comprising eluting an ion exchange column with a water-soluble silver salt to obtain Ag18F, wherein the ion exchange column has been loaded with 18F−.
A kit comprising a water-soluble silver salt and an ion exchange column loaded with 18F−.
A method of preparing Ag18F comprising eluting an ion exchange column with a water-soluble salt to obtain a 18F salt, wherein the ion exchange column has been loaded with 18F−, and combining the 18F salt with a silver salt to obtain Ag18F.
Dependencies are inferred from the claim text.