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US 2016/0314241 A1Published application
Drug discovery method
AssigneeKeddem Bioscience Ltd.
InventorDror OFER
Life of this patent
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Abstract
A method of obtaining information about a chemically active area of a target molecule, for example for drug discovery, comprising: providing a set of substantially rigid chemical gauges; reacting said target with a plurality of gauges of said set of gauges; assaying a binding of said gauges with said target to obtain a plurality of assay results; and analyzing said assay results to obtain information about said chemically active area.
Claims20
A method for lead construction, comprising the following steps:
- (a) providing a library of molecules;
- (b) generating a pharmacophore map of a target molecule by (i) successfully binding at least 20 low-mass chemical gauges with said target molecule and (ii) analyzing the result of said binding;
- (c) computationally screening said library of molecules against said pharmacophore map to identify at least one molecule of said library of molecules that compliments at least 3 points of said pharmacophore map;
- (d) computationally modifying said at least one molecule to provide at least one additional attachment point between said molecule and said pharmacophore map by removing moieties and/or adding moieties, to provide said at least one additional attachment point;
- and
- (e) using said at least one molecule to construct said lead.
3 more elements
Dependencies are inferred from the claim text.