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US 2016/0310448 A1Published application
Adamantane or Pinene Derivatives for Use in the Treatment of Chlamydiales Infections
AssigneeCommissariat A L'energie Atomique Et Aux Energies Alternatives
InventorsDaniel Gillet, Julien Barbier, Jean-Christophe Cintrat, Valérie Pons, Thomas Rudel, Jo-Ana Herweg, Annette Fischer
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Abstract
The present invention relates to a method for treating a Chlamydiales infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof: W—L1—NH—L2—Ar (I) Wherein W, L1, L2 and Ar are as defined in claim 1.
Claims13
A method for treating a Chlamydiales infection comprising the administration of a therapeutically effective amount of a compound of formula (I) to a subject in need thereof
- W—L1—NH—L2—Ar (I)
- Wherein:
- W is independently selected from:
- an adamantyl optionally substituted by one or more C1-C6 alkyl groups, or
- a saturated pinanyl
- L1 is independently selected from a single bond W—N, —(CH2)pC(═O)—,
- L2 is independently selected from —(CH2)q—, [—C(═O)—NH]r—N═CH—, or —(C6H4)—SO2—NH—,
- Ar is a C6-C10 aryl or a 5 to 10 membered heteroaryl, said aryl or heteroaryl groups being optionally substituted by one to three R groups,
- R is independently selected from F, Cl, Br, I, C1-C6 alkyl, C1-C6 alkoxy, NO2,
- p is 0, 1, or 2,
- q is 1 or 2,
- r is 0 or 1,
- and the stereoisomeric forms, mixtures of stereoisomeric forms or pharmaceutically acceptable salts forms thereof.
10 more elements
Dependencies are inferred from the claim text.