Nanoparticle contrast agents for diagnostic imaging
AssigneeGeneral Electric Company
InventorsMatthew David Butts, Robert Edgar Colborn, Peter John Bonitatibus, JR., Andrew Soliz Torres
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Abstract
Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprising a nanoparticulate transition metal oxide covalently functionalized with a silane-functionalized non-targeting zwitterionic moiety.
Claims12
A nanoparticle composition comprising nanoparticles having idealized structure IV, the nanoparticles comprising a functionalized nanoparticulate metal oxide and a trioxysilane betaine ligand
- wherein R2 is independently at each occurrence a C1-C3 alkyl group;
- R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group;
- n is 0, 1, 2 or 3;
- q is 1, 2 or 3;
- and the functionalized nanoparticulate metal oxide comprises nanoparticulate tantalum oxide.
A diagnostic imaging agent composition comprising nanoparticles having idealized structure IV, the nanoparticles comprising a functionalized nanoparticulate metal oxide and a trioxysilane betaine ligand
- wherein R2 is independently at each occurrence a C1-C3 alkyl group;
- R3 is independently at each occurrence a hydrogen or a C1-C3 alkyl group;
- n is 0, 1, 2 or 3;
- q is 1, 2 or 3;
- and the functionalized nanoparticulate metal oxide comprises nanoparticulate tantalum oxide.
Dependencies are inferred from the claim text.