US 2016/0291016 A1 · NEW MARKERS FOR SEVERE PROGRESSION OF IDIOPATHIC SCOLIOSIS AND USES THEREOF TO STRATIFY SCOLIOTIC PATIENTS AND PREDICT THE RISK OF DEVELOPING SCOLIOSIS

Abstract

Methods of stratifying a subject having or at risk for developing adolescent idiopathic scoliosis (AIS) into diagnostically or clinically useful subclasses are provided. The stratification is based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity. Also provided are methods of predicting the risk of developing a scoliosis also based on the subject's PTPμ expression and/or activity and/or PIPK1γ expression and/or activity; and methods of increasing GiPCR signaling in cells of a subject in need thereof comprising administering to the subject's cells an effective amount of an inhibitor of PIPK1γ tyrosine phosphorylation; an activator of PIPK1Y tyrosine dephosphorylation; and/or an inhibitor of PIPK1γ expression and/or activity.

Claims23

Dependent claims

A method of stratifying a subject having or at risk of developing scoliosis, or of predicting the risk of developing a scoliosis in said subject said method comprising:

(i) providing a cell sample isolated from the subject;
(ii) (a) detecting PTPμ expression and/or activity in the cell sample;
(b) detecting PIPK1γ expression and/or activity in the cell sample;
or
(c) a combination of (a) and (b);
and
(iii) (a) stratifying said subject into a AIS subclass based on the level of expression or activity of PTPμ and/or PIPK1γ in the cell sample of the subject;
or
(b) determining that the subject is at risk of developing a scoliosis when:
(1) PTPμ expression and/or activity is decreased;
and/or
(2) PIPK1γ expression and/or activity is increased;
in the subject's sample as compared to a level in a control sample.

10 more elements

Dependencies are inferred from the claim text.

New markers for severe progression of idiopathic scoliosis and uses thereof to stratify scoliotic patients and predict the risk of developing scoliosis

Life of this patent

New markers for severe progression of idiopathic scoliosis and uses thereof to stratify scoliotic patients and predict the risk of developing scoliosis

Life of this patent

Abstract

Claims23