Cyclic peptide compound, and preparation method, pharmaceutical composition and use thereof

A compound with a chemical structure shown as formula (I), its isomers, racemates, pharmaceutically acceptable salts, crystalline hydrate, and solvate or their mixture:

• wherein,
• R1 is hydrogen, C1-16 alkyl, C3-16 cycloalkyl, —(C═O)—(C1-16 alkyl), —(C═S)—(C1-16 alkyl) or —S—(C1-16 alkyl);
• R2 is hydrogen, C1-12 alkyl, —CH2—O—(C1-12 alkyl), —CH2—NH—(C1-12 alkyl), —CH2—S—(C1-12 alkyl), C6-12 aryl, heteroaryl, —CH2—(C6-12 aryl) or —CH2— heteroaryl;
• wherein the C6-12 aryl, heteroaryl, —CH2—C6-12 aryl, —CH2— heteroaryl, comprise one or more substituents and the one or more substituents are selected from halo, amino, hydroxyl, nitro, cyano, C1-12 alkyl, C1-12 alkoxy, amino C1-12 alkyl, acyl, acyloxy, thio C1-12 alkyl, carboxyl or phenyl;
• R3, R4 are independently selected from hydrogen, C1-12 alkyl, —O—(C1-12 alkyl), —NH—(C1-12 alkyl), —S—(C1-12 alkyl), C6-12 aryl and heteroaryl;
• one of X and Y is C, the other is N, or both X and Y are N;
• R5, R6, R7 are independently selected from hydrogen, halo, —S—(C1-12 alkyl), C1-12 alkyl and t-butoxycarbonyl;
• Z is independently —CH2—, —NH—, —O—, —S— or
• m is independently 0, 1, 2, 3, 4, 5 or 6.