Internalizing ErbB2 Antibodies
AssigneeThe Regents of the University of California
InventorsJames D. Marks, Marie Alix Poul
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Abstract
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalizing into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.
Claims17
An internalizing antibody that specifically binds to an ErbB2 epitope bound by a C1 antibody comprising the amino acid sequence set forth in SEQ ID NO:
- 2, which internalizing antibody binds to ErbB2 with an affinity of 10−5M to 10−12M and shares at least 70% sequence identity with the amino acid sequence of SEQ ID NO:
- 1 or SEQ ID NO:
- 2.
An internalizing antibody comprising the six CDRs of a C1 antibody comprising the amino acid sequence set forth in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.