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US 2016/0279205 A1Published application
Compositions and Methods for Enzymatic Treatment of Lung Disorders
AssigneeLaclede, Inc.
InventorsMichael Pellico, Pamela Bosco
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Abstract
A therapeutic composition for the treatment of lung diseases or disorders and diseases or disorders of the airway passages including pneumonia, acute respiratory failure, and acute respiratory distress syndrome is based on the generation of a biocidal anion by an enzymatic reaction catalyzed by a peroxidase. The peroxide utilized by the peroxidase enzyme can be endogenous or can be generalized by the action of an oxidase enzyme on a suitable substrate.
Claims30
A method comprising the step of administering a therapeutic composition comprising:
- (a) a peroxidase enzyme that catalyzes a reaction between hydrogen peroxide and a salt that acts as an oxygen acceptor and is capable of reacting with hydrogen peroxide to form a biocide, the peroxidase enzyme being present in a sufficient quantity such that the biocide is produced in a therapeutically effective concentration;
- (b) a salt that acts as an oxygen acceptor and is capable of reacting with hydrogen peroxide to form a biocide in a quantity sufficient to form a therapeutically effective concentration of the biocide;
- and
- (c) an aqueous medium in which the peroxidase enzyme and the salt that acts as an oxygen acceptor are stable, to a patient suffering from a lung disease or condition by a route in which the ingredients of the composition reach the lungs and generate the biocide within the lungs to treat the lung disease or condition.
1 more element
Dependencies are inferred from the claim text.