Bunyaviruses with segmented glycoprotein precursor genes and methods for generating these viruses
AssigneeStichting Dienst Landbouwkundig Onderzoek
InventorsJeroen Alexander Kortekaas, Paulus-Jozef Wichgers Schreur, Nadia Dimitrova Oreshkova, Robertus Jacobus Maria Moormann
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Abstract
The invention relates to a bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two different genome segments, preferably a bunyavirus that comprises a total of at least 4 genome segments. The invention further relates to methods for producing said bunyavirus, and to a composition comprising said bunyavirus and a suitable excipient.
Claims15
A bunyavirus, in which separated (NSm)Gn and Gc coding regions are functionally present on two separate genome segments.
A method for generating a bunyavirus, the method comprising:
- A) providing a cell with a bunyavirus comprising at least one genome segment functionally encoding a RdRp gene and an N gene, and B) providing the cell with at least two (mini)genome segments selected from L, M, and/or S genome segments in which separated (NSm)Gn and Gc coding regions are functionally present on two separate genome segments.
Dependencies are inferred from the claim text.