Tissue Targeted Antigenic Activation of the Immune Response to Treat Cancers

A method for treating a human patient for a cancer situated in a lung tissue, the method comprising:

• administering to the patient a medicament comprising an effective amount of an antigenic composition comprising whole killed or attenuated cells of one or more microbial pathogen, wherein the microbial pathogen is selected from the group consisting of Klebsiella pneumoniae, Streptococcus pneumoniae, Moraxella catarrhalis, Mycoplasma pneumoniae, Haemophilus influenza, influenza virus, adenovirus, respiratory syncytial virus, and parainfluenza virus;
• administering the medicament in successive doses given at a dosage interval of between one hour and one month, over a dosage duration of at least two weeks in an amount and for a time that is effective to modulate an immune response, and the modulation of the immune response comprises a shift in the activation state of macrophages from a M2-like macrophage response to a M1-like macrophage response;
• and,
• administering to the patient an effective amount of cisplatin.