Producing a Separation Medium Using Grayscale Mask
AssigneeThe Regents of the University of California
InventorsChi-Chih KANG, Amy E. HERR, Todd A. DUNCOMBE
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Abstract
Provided are methods for producing a separation medium, where the method includes exposing a separation medium precursor solution to light from a light source through a photomask that includes a region with varied light transmittance to produce the separation medium. Systems that find use in performing the methods, microfluidic devices that include the separation medium, as well as methods of using the microfluidic devices, are also provided. Embodiments of the present disclosure find use in a variety of different applications, including detecting whether an analyte is present in a fluid sample.
Claims22
A method for producing a spatially varied separation medium, the method comprising:
- exposing a separation medium precursor solution to light from a light source through a photomask comprising a region with varied light transmittance to produce the separation medium.
A microfluidic device comprising:
- a support;
- and
- a separation medium associated with the support and configured to separate a sample along a directional axis, wherein the separation medium has a homogeneous composition and comprises regions having different degrees of polymerization.
A system for producing a separation medium, the system comprising:
- a support configured to contain a separation medium precursor solution;
- a photomask comprising a semi-transparent region;
- and
- a light source configured to direct a light from the light source to the separation medium precursor solution through the photomask.
Dependencies are inferred from the claim text.