# US 2016/0257643 A1 · Amino acid derivatives and absorbable polymers therefrom

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- Number: US 2016/0257643 A1
- Document ID: US20160257643A1
- Status: Published application
- Kind: A1
- Application number: 14/979,782
- Filed: 2015-12-28
- Published: 2016-09-08
- Earliest claimed: 2011-02-11
- Assignees: Bezwada Biomedical, LLC
- Applicants: Bezwada Biomedical, LLC
- Inventors: Rao S. Bezwada
- Web page: https://patentgrep.com/patent/US20160257643A1

## CPC

- C07C 235/12: having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- A61L 15/26: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)}
- A61L 17/10: containing macromolecular materials
- A61L 24/046: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L24/043 takes precedence)}
- A61L 26/0019: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds}
- A61L 27/18: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- A61L 31/06: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)}
- A61L 31/10: Macromolecular materials
- C07C 229/36: with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
- C07C 229/42: with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
- C07C 235/10: having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
- C07C 237/36: having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C 265/12: having isocyanate groups bound to carbon atoms of six-membered aromatic rings
- C07C 265/14: containing at least two isocyanate groups bound to the same carbon skeleton
- C08G 18/38: having heteroatoms other than oxygen (C08G18/32 takes precedence)
- C08G 18/48: Polyethers
- C08G 18/4837: {and other oxyalkylene units}
- C08G 18/6607: {with compounds of group C08G18/3203}
- C08G 18/771: {oxygen}
- C08G 18/7812: {containing amide groups}
- A61L 2420/00: Materials or methods for coatings medical devices
- C08G 2101/00: Manufacture of cellular products
- Y10T 428/139: Open-ended, self-supporting conduit, cylinder, or tube-type article
- Y10T 428/249921: Web or sheet containing structurally defined element or component
- Y10T 442/10: Scrim [e.g., open net or mesh, gauze, loose or open weave or knit, etc.]
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

## Claims

### Claim at position 1

1-18. (canceled)

### Claim 19

An amide diacid selected from formula W:
wherein:
Q is the residue of a symmetrical or unsymmetrical ether acid;
Rx is the residue of a diamine and is selected from: alkyl, aryl, and arylalkyl-, alternatively, Rx is the residue of a diamino-amino acid or amino acid analog.

### Claim 20 (depends on 19)

An amide diacid of claim 19, wherein Rx is selected from L-lysine, L-Lysine methyl ester, and aminophenyl alanine.

### Claim 21 (depends on 20)

An amide diacid of claim 20, wherein Rx is the residue of L-lysine.

### Claim 22 (depends on 20)

An amide diacid of claim 20, wherein Rx is the residue of L-Lysine methyl ester.

### Claim 23 (depends on 20)

An amide diacid of claim 20, wherein Rx is the residue of aminophenyl alanine.

### Claim 24 (depends on 19)

The amide diacid of claim 19, wherein the diacid is selected from the formulas:

### Claim 25 (depends on 24)

The amide diacid of claim 24, wherein the diacid is of formula W1.

### Claim 26 (depends on 24)

The amide diacid of claim 24, wherein the diacid is of formula W2.

### Claim 27 (depends on 24)

The amide diacid of claim 24, wherein the diacid is of formula W3.

### Claim 28 (depends on 19)

The amide diacid of claim 19, wherein the symmetrical or unsymmetrical ether acid is selected from:

### Claim 29 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 30 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 31 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 32 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 33 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 34 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 35 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 36 (depends on 28)

The amide diacid of claim 28, wherein the symmetrical or unsymmetrical ether acid is:

### Claim 37 (depends on 19)

The amide diacid of claim 19, wherein the diacid is of the formula:

### Claim 38 (depends on 19)

The amide diacid of claim 19, wherein the diacid is of the formula:

### Claim 39 (depends on 19)

The amide diacid of claim 19, wherein the diacid is of the formula: