# US 2016/0256540 A1 · Methods And Compositions For Treatment Of S. Equi Infection

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- Number: US 2016/0256540 A1
- Document ID: US20160256540A1
- Status: Published application
- Kind: A1
- Application number: 15/028,814
- Filed: 2014-10-15
- Published: 2016-09-08
- Earliest claimed: 2013-10-17
- Assignees: Zoetis Services LLC
- Applicants: Zoetis Services LLC
- Inventors: Ellen Ons; Rudiger Raue
- Web page: https://patentgrep.com/patent/US20160256540A1

## CPC

- A61K 39/275: Poxviridae, e.g. avipoxvirus
- A61K 39/12: Viral antigens
- A61P 31/04: Antibacterial agents
- A61K 2039/5252: {inactivated (killed)}
- A61K 2039/552: {Veterinary vaccine}
- A61K 2039/58: {raising an immune response against a target which is not the antigen used for immunisation}
- C12N 2710/24234: Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)

## Abstract

The instant invention provides methods for treatment or prevention of S equi and/or EHV in horses, the methods comprising administered to the horses in need thereof a com position comprising parapoxvirus ovis.

## Claims

### Claim 1

A method of protecting a horse in need thereof against a Streprococcus equi equi (Strep equi) infection comprising administering to said horse an immunologically effective amount of Parapoxvirus Ovis.

### Claim 2 (depends on 1)

The method of claim 1, wherein said horse is not effectively immunized against Strep equi.

### Claim 3 (depends on 1)

The method of claim 1, wherein said horse is infected with EHV-1.

### Claim 4

A method of protecting a horse against concurrent Strep Equi and EHV infections, comprising administering to said horse an immunologically effective amount of Parapoxvirus ovis.

### Claim 5 (depends on 4)

The method of claim 4, wherein said horse is not effectively immunized against Strep equi and EHV.

### Claim 6 (depends on 1)

The method of claim 1, wherein said Parapoxvirus ovis is an inactivated Parapoxvirus ovis.

### Claim 7 (depends on 1)

The method of claim 1, wherein said Parapoxvirus Ovis comprises Parapoxvirus ovis strain D1701.

### Claim 8 (depends on 1)

The method of claim 1, wherein said Parapoxvirus ovis is administered in an aqueous composition.

### Claim 9 (depends on 8)

The method of claim 8, wherein said aqueous composition lacks an adjuvant.

### Claim 10 (depends on 1)

The method of claim 1, wherein said composition is administered intramuscularly.

### Claim 11 (depends on 1)

The method of claim 1, wherein the effective amount of said Parapoxvirus ovis is between 1 RP per dose and 11.6 RP per dose.

### Claim 12 (depends on 1)

The method of claim 1, wherein said immunologically effective amount of the Parapoxvirus ovis is administered to the horse three times, and wherein the second administration occurs about 2 days after the first administration, and wherein the third administration occurs about 2 to about 10 days after the second administration.

### Claim 13 (depends on 12)

The method of claim 12, wherein the third administration occurs about seven days after the second administration.