# US 2016/0256407 A1 · Energy patch > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2016/0256407 A1 - Document ID: US20160256407A1 - Status: Published application - Kind: A1 - Application number: 15/027,910 - Filed: 2014-10-10 - Published: 2016-09-08 - Earliest claimed: 2013-10-11 - Assignees: Xep, Inc. - Applicants: Xep, Inc. - Inventors: Servet Buyuktimkin; Nadir Buyuktimkin; James L. Yeager - Web page: https://patentgrep.com/patent/US20160256407A1 ## CPC - A61K 9/7061: {Polyacrylates} - A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir - A61K 36/5777: {Theobroma, e.g. cocao or cocoa} - A61K 36/77: Sapindaceae (Soapberry family), e.g. lychee or soapberry - C07D 473/12: with methyl radicals in positions 1, 3, and 7, e.g. caffeine - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) ## Abstract A transdermal patch suitable for releasing a stimulant such as caffeine for an extended time period utilizes a pressure sensitive acrylic adhesive matrix constituted by an acrylic adhesive having hydroxy groups and an acrylic adhesive without hydroxy, groups, preferably in a respective weight ratio of about 2 to about 3. A suitable caffeine source is caffeine-fortified guarana seed extract, caffeine, a caffeine salt, and the like. ## Claims ### Claim 1 A transdermal patch comprising a backing layer; a pressure-sensitive acrylic adhesive matrix on the backing layer; and a xanthine composition comprising guarana seed extract and caffeine in said matrix; and a protective release sheet over the pressure-sensitive acrylic adhesive matrix; the pressure-sensitive acrylic adhesive matrix comprising a mixture of an acrylic adhesive having hydroxy groups and an acrylic adhesive without hydroxy groups. ### Claim 2 (depends on 1) The transdermal patch in accordance with claim 1 wherein the xanthine composition is present in the matrix in an amount in the range of about 5 to about 50 percent by weight, based on the total weight of the adhesive matrix. ### Claim 3 (depends on 1) The transdermal patch in accordance with claim 1 wherein the acrylic adhesive having hydroxy groups and the acrylic adhesive without hydroxy groups are present in the matrix in a respective weight ratio in the range of about 0.5 to about 5. ### Claim 4 (depends on 1) The transdermal patch in accordance with claim 1 wherein the acrylic adhesive having hydroxy groups and the acrylic adhesive without hydroxy groups are present in the matrix in a respective weight ratio of about 2 to about 3. ### Claim 5 (depends on 1) The transdermal patch in accordance with claim 1 wherein the pressure-sensitive acrylic adhesive matrix further contains polyvinylpyrrolidone and propylene glycol. ### Claim 6 (depends on 1) The transdermal patch in accordance with claim 1 wherein the polyvinyl pyrrolidone is present in an amount in the range of about 2 to about 5 percent by weight of the total weight of the adhesive matrix and has a weight average molecular weight in the range of about 2,000 to about 11,000 Daltons, and propylene glycol is present in an amount in the range of about 2 to about 10 percent by weight of the total weight of the adhesive matrix. ### Claim 7 (depends on 1) The transdermal patch in accordance with claim 1 wherein the thickness of pressure-sensitive acrylic adhesive matrix is in the range of about 3 mils to about 5 mils. ### Claim 8 (depends on 1) The transdermal patch in accordance with claim 1 wherein the xanthine composition comprises a caffeine fortified guarana seed extract and caffeine. ### Claim 9 (depends on 8) The transdermal patch in accordance with claim 8 further containing cocoa. ### Claim 10 (depends on 9) The transdermal patch in accordance with claim 9 and containing about 0.5 to about 5 percent by weight cocoa, based on total weight of the adhesive matrix. ### Claim 11 (depends on 8) The transdermal patch in accordance with claim 8 wherein the caffeine is present in an amount in the range of about 6 to about 40 percent by weight of the total weight of the adhesive matrix, and cocoa is present in an amount in the range of about 1 to about 3 percent by weight, based on total weight of the adhesive matrix. ### Claim 12 (depends on 1) The transdermal patch in accordance with claim 1 wherein the acrylic adhesive having hydroxy groups is a self-crosslinking acrylic copolymer of 2-hydroxyethyl acrylate, 2-ethylhexyl acrylate, acrylic acid, and methyl methacrylate, containing aluminum acetonate and t-amyl peroxypivalate as cross-linking agents, and wherein the acrylic adhesive without hydroxy groups is a copolymer of 2-ethylhexyl acrylate, acrylic acid, butyl acrylate and vinyl acetate. ### Claim 13 (depends on 1) The transdermal patch in accordance with claim 1 wherein the release sheet is a silicone treated polyurethane film. ### Claim 14 (depends on 1) The transdermal patch in accordance with claim 1 wherein the foam backing layer is an ethylene-vinyl acetate foam. ### Claim 15 (depends on 1) The transdermal patch in accordance with claim 1 wherein the adhesive matrix is at least 3 mils thick. ### Claim 16 A transdermal patch comprising an occlusive foam backing layer; a pressure-sensitive acrylic adhesive matrix on the backing layer; guarana seed extract in said adhesive matrix; caffeine in said adhesive matrix; cocoa in said adhesive matrix; and the adhesive matrix comprising a mixture of an acrylic adhesive having hydroxy groups and an acrylic adhesive without hydroxy groups. ### Claim 17 (depends on 16) The transdermal patch in accordance with claim 16 further including arnica in said adhesive matrix. ### Claim 18 (depends on 16) The transdermal patch in accordance with claim 16 containing about 2.5 percent by weight caffeine fortified guarana seed extract, about 6 percent by weight caffeine, and about 1 percent by weight cocoa, based on total weight of the adhesive matrix, and wherein the weight ratio of acrylic adhesive having hydroxy groups to acrylic adhesive without hydroxy groups is about 2.9. ### Claim 19 (depends on 16) The transdermal patch in accordance with claim 16 further containing up to about 10 percent by weight arnica extract, based on total weight of the adhesive matrix. ### Claim 20 (depends on 1) The transdermal patch in accordance with claim 1 further containing an arnica extract in an amount of up to about 10 percent by weight, based on total weight of the adhesive matrix.