# US 2016/0256376 A1 · Use of glycosaminoglycan lipoate esters in the trichology field

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- Number: US 2016/0256376 A1
- Document ID: US20160256376A1
- Status: Published application
- Kind: A1
- Application number: 15/062,406
- Filed: 2016-03-07
- Published: 2016-09-08
- Earliest claimed: 2010-12-15
- Assignees: Sigea S.R.L.
- Applicants: Sigea S.R.L.
- Inventors: Marco Bosco; Luca Stucchi; Matteo Fabbian; Fabrizio Picotti
- Web page: https://patentgrep.com/patent/US20160256376A1

## CPC

- A61K 8/735: {Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof}
- A61K 8/0216: {Solid or semisolid forms}
- A61K 8/062: {Oil-in-water emulsions}
- A61K 8/27: Zinc; Compounds thereof
- A61K 8/736: {Chitin; Chitosan; Derivatives thereof}
- A61P 17/04: Antipruritics
- A61P 17/14: for baldness or alopecia
- A61Q 5/006: {Antidandruff preparations}
- A61Q 5/02: Preparations for cleaning the hair
- A61Q 5/06: Preparations for styling the hair, e.g. by temporary shaping or colouring
- A61Q 5/12: Preparations containing hair conditioners
- A61Q 7/00: Preparations for affecting hair growth
- A61K 2800/596: Mixtures of surface active compounds
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Disclosed is the use of glycosaminoglycan esters, whose alcohol groups are partly esterified with lipoic acid or with lipoic acid and formic acid, in hair care treatments.

## Claims

### Claim at position 1

1-9. (canceled)

### Claim 10

Topical compositions for hair care comprising hyaluronic acid esters wherein the alcohol groups of the hyaluronic acid are partially esterified with lipoic acid or with lipoic acid and formic acid.

### Claim 11 (depends on 10)

Topical compositions according to claim 10, wherein the carboxyl function of the hyaluronic acid esters is present in acid form or salified with alkali metals, and the sulphate function, when present, is salified with alkali metals.

### Claim 12 (depends on 10)

Topical compositions according to claim 10, wherein the molecular weight of the esters ranges from 103 to 107 Dalton.

### Claim 13 (depends on 10)

Topical compositions according to claim 10, wherein the molecular weight of the esters ranges from 104 to 106 dalton.

### Claim 14 (depends on 10)

Topical compositions according to claim 10 wherein the degree of esterification of lipoic acid on the hyaluronic acid hydroxyls ranges from 0.01 to 1*N, wherein N is the number of free alcohol group present in the repeating unit, while the degree of esterification of formic acid on the hyaluronic acid hydroxyls ranges from 0 to 0.20.

### Claim 15 (depends on 10)

Topical compositions according to claim 10, wherein the degree of esterification of lipoic acid on the hyaluronic acid hydroxyls ranges from 0.01 to 0.2*N, wherein N is the number of free alcohol groups present in the repeating unit, while the degree of esterification of formic acid on the hyaluronic acid hydroxyls ranges from 0 to 0.20.

### Claim 16 (depends on 10)

Topical compositions according to claim 10, further comprising a zinc salt and/or a silver salt in a molar ratio of between 0.1 and 10 of metal to the lipoic acid content.