# US 2016/0256170 A1 · Systems and methods for the treatment of aneurysms > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2016/0256170 A1 - Document ID: US20160256170A1 - Status: Published application - Kind: A1 - Application number: 14/212,930 - Filed: 2014-03-14 - Published: 2016-09-08 - Earliest claimed: 2013-03-15 - Assignees: Arsenal Medical, Inc. - Inventors: Rany Busold; John Marini; Upma Sharma; Adam Rago; Jennifer Mortensen; Joseph Lomakin; Gregory T. Zugates; Janet Komatsu - Web page: https://patentgrep.com/patent/US20160256170A1 ## CPC - A61B 17/12118: {for positioning in conjunction with a stent} - A61B 17/12186: {liquid materials adapted to be injected} - A61B 17/1219: {expandable in contact with liquids} - A61B 17/12195: {comprising a curable material} - A61F 2/07: Stent-grafts - A61F 2/95: Instruments specially adapted for placement or removal of stents or stent-grafts - A61M 25/0067: {characterised by the distal end, e.g. tips (A61M25/0054, A61M25/04 take precedence; balloon catheters A61M25/10)} - A61B 2017/1205: {Introduction devices} - A61B 2217/005: with suction drainage system - A61F 2002/077: {having means to fill the space between stent-graft and aneurysm wall, e.g. a sleeve} - A61M 25/007: {Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked} - A61M 25/0074: {Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable} - A61M 25/10: Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00}) - A61M 25/1006: {Balloons formed between concentric tubes} - A61M 2025/0004: {having two or more concentrically arranged tubes for forming a concentric catheter system} - A61M 2025/0078: {for fluid inflow from the body into the catheter lumen} - A61M 2025/0175: {having telescopic features, interengaging nestable members movable in relations to one another} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up. ## Claims ### Claim 1 A system for treating a patient, comprising: an endoprosthesis configured to span an aneurysm; and a formulation adapted to form a polymer foam when exposed to blood, the formulation configured to float in blood. ### Claim 2 (depends on 1) The system of claim 1, wherein the aneurysm is characterized by a top and a bottom, and the formulation, when disposed within the aneurysm, floats to the top and generates a foam that expands to occupy at least a portion of the volume of the aneurysm from the top down. ### Claim 3 (depends on 2) The system of claim 2, further comprising a catheter having a tip that is positionable at the bottom of the aneurysm, wherein the catheter is configured to permit at least one of the discharge of the formulation into the aneurysm and the inflow of blood displaced by a downward expansion of the foam. ### Claim 4 (depends on 3) The system of claim 3, wherein the catheter includes a first lumen configured to discharge the formulation into the aneurysm and a second lumen configured to permit the inflow of blood displaced by the downward expansion of the foam. ### Claim 5 (depends on 3) The system of claim 3, wherein the tip of the catheter is sized to fit within a lumbar artery. ### Claim 6 (depends on 3) The system of claim 3, wherein the tip of the catheter is sized to fit through one of a fenestration within the endoprosthesis and a space between the endoprosthesis and a blood vessel fluidly connected to the aneurysm. ### Claim 7 (depends on 3) The system of claim 3, wherein the tip of the catheter includes a retractable shield adapted to inhibit the migration of the formulation from the bottom of the aneurysm to the top. ### Claim 8 (depends on 1) The system of claim 1, wherein the endoprosthesis is a stent graft. ### Claim 9 (depends on 1) The system of claim 1, wherein the endoprosthesis is a catheter balloon and is configured to be removed after a foam has been formed between an outer surface of the catheter balloon and an inner surface of the aneurysm. ### Claim 10 A system for treating a patient, comprising: an endoprosthesis configured to span an aneurysm; and a formulation adapted to form a polymer foam when exposed to a body fluid, the formulation having a buoyancy less than that of blood. ### Claim 11 (depends on 10) The system of claim 10, wherein the aneurysm is characterized by a top and a bottom, and the formulation, when disposed within the aneurysm, sinks to the bottom and generates a foam that expands to occupy at least a portion of the volume of the aneurysm from the bottom up. ### Claim 12 (depends on 11) The system of claim 11, further comprising a catheter having a tip that is positionable at the top of the aneurysm, wherein the catheter is configured to permit at least one of the discharge of the formulation into the aneurysm and the inflow of blood displaced by an upward expansion of the foam. ### Claim 13 (depends on 12) The system of claim 12, wherein the catheter includes a first lumen configured to discharge the formulation into the aneurysm and a second lumen configured to permit the inflow of blood displaced by the upward expansion of the foam. ### Claim 14 (depends on 12) The system of claim 12, wherein the tip of the catheter is sized to fit within an inferior mesenteric artery. ### Claim 15 (depends on 12) The system of claim 12, wherein the tip of the catheter is sized to fit through one of a fenestration within the endoprosthesis and a space between the endoprosthesis and a blood vessel fluidly connected to the aneurysm. ### Claim 16 (depends on 12) The system of claim 12, wherein the tip of the catheter includes a retractable shield adapted to inhibit the migration of the formulation from the top of the aneurysm to the bottom. ### Claim 17 (depends on 10) The system of claim 10, wherein the endoprosthesis is a stent graft. ### Claim 18 (depends on 10) The system of claim 10, wherein the endoprosthesis is a catheter balloon and is configured to be removed after a foam has been formed between an outer surface of the catheter balloon and an inner surface of the aneurysm. ### Claim 19 A system for treating a patient, comprising: an endoprosthesis configured to span an abdominal aortic aneurysm; a formulation configured to form a polymer foam within the abdominal aortic aneurysm; and a delivery catheter insertable through one of an inferior mesenteric artery, a lumbar artery, a fenestration within the endoprosthesis and a space between the endoprosthesis and a wall of a blood vessel adjoining the abdominal aortic aneurysm, wherein the formulation is configured to migrate away from the delivery catheter and to form a foam within the abdominal aortic aneurysm that expands toward the delivery catheter.