# US 2016/0249934 A1 · Filamentary devices for treatment of vascular defects > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2016/0249934 A1 - Document ID: US20160249934A1 - Status: Published application - Kind: A1 - Application number: 14/684,079 - Filed: 2015-04-10 - Published: 2016-09-01 - Earliest claimed: 2013-08-16 - Assignees: Sequent Medical, Inc. - Applicants: Sequent Medical, Inc. - Inventors: Todd Hewitt; Brian Merritt; William R. Patterson; James M. Thompson; Claudio Plaza; Hung P. Tran - Web page: https://patentgrep.com/patent/US20160249934A1 ## CPC - A61B 17/12113: {within an aneurysm} - A61B 17/12013: {for use in minimally invasive surgery, e.g. endoscopic surgery} - A61B 17/12031: {complete occlusion} - A61B 17/12118: {for positioning in conjunction with a stent} - A61B 17/12145: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)} - A61B 17/12172: {having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526)} - A61B 17/12177: {comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated} - A61B 17/12186: {liquid materials adapted to be injected} - A61B 2017/00292: {mounted on or guided by flexible, e.g. catheter-like, means} - A61B 2017/00526: {Methods of manufacturing} - A61B 2017/00539: {hydraulically} - A61B 2017/00778: {Operations on blood vessels (A61B2017/22097, A61B2017/320741 take precedence)} - A61B 2017/00862: {elastic or resilient} - A61B 2017/00867: {shape memory effect} - A61B 2017/1205: {Introduction devices} - A61B 2017/12068: {detachable by heat} - A61B 2017/1209: {detachable by electrical current or potential, e.g. electroactive polymer} - A61B 2017/12095: {Threaded connection} - A61B 2090/3966: {Radiopaque markers visible in an X-ray image} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Devices and methods for treatment of a patient's vasculature are described. The devices include implants made of woven braided mesh having a variable mesh density, i.e., the average size of pores in one region are a different than the average size of pores in another region. Additionally, there is a transition zone between the two regions. The implants have a low profile radially constrained state and an expanded state that is axially shortened. Methods of using the device to treat a cerebral aneurysm are also described. Methods of forming a tubular braid are also described. Methods of forming a tubular braid with variable braid densities are described. Methods of forming a tubular braid using a castellated mandrel are also described. ## Claims ### Claim 1 A device for treating a cerebral aneurysm, comprising: an implant comprising woven braided mesh, the implant having a proximal end with a hub, a distal end, and a longitudinal axis extending from the proximal end to the distal end; the implant having a distal region, a proximal region, and a transition region that lies substantially perpendicular to the longitudinal axis of the implant and extends between the distal and proximal regions; the implant having an expanded configuration when deployed, the expanded implant having a region of maximum diameter that extends from a proximal portion of the distal region through the transition region and to a distal portion of the proximal region, wherein a diameter of a pore within the proximal portion of the distal region is larger than all pores in the distal portion of the proximal region. ### Claim 2 (depends on 1) The device of claim 1, wherein the diameter of a pore in the proximal portion of the distal region is greater than 300 μm. ### Claim 3 (depends on 1) The device of claim 1, wherein the diameter of a pore in the proximal portion of the distal region is between about 300 μm and about 900 μm. ### Claim 4 (depends on 1) The device of claim 1, wherein the diameter of a pore in the proximal portion of the distal region is in a range selected from the group consisting of about 300 μm to about 900 μm, about 300 μm to about 700 μm, and about 300 μm to about 500 μm. ### Claim 5 (depends on 1) The device of claim 1, wherein the diameter of a pore in the distal portion of the proximal region is less than 200 μm. ### Claim 6 (depends on 1) The device of claim 1, wherein the diameter of a pore in the distal portion of the proximal region is between about 50 μm and about 200 μm. ### Claim 7 (depends on 1) The device of claim 1, wherein the diameter of a pore in the distal portion of the proximal region is in a range selected from the group consisting of about 50 μm to about 200 μm, about 50 μm to about 150 μm, and about 100 μm to about 200 μm ### Claim 8 (depends on 1) The device of claim 1, wherein the transition region is approximately 1000 μm high. ### Claim 9 (depends on 1) The device of claim 1, wherein the transition region has a height that is approximately about 0.5% to about 20% of a total height of the implant. ### Claim 10 (depends on 1) The device of claim 1, wherein the transition region has a height that is selected from the group consisting of approximately about 1% to about 15% of a total height of the implant, about 1% to about 10% of a total height of the implant, and about 3% to about 8% of a total height of the implant. ### Claim 11 A method for treating a cerebral aneurysm, comprising the steps of: providing an implant comprising woven braided mesh, the implant having a proximal end with a hub, a distal end, and a longitudinal axis extending from the proximal end to the distal end, wherein the implant has a distal region, a proximal region, and a transition region that lies substantially perpendicular to the longitudinal axis of the implant and extends between the distal and proximal regions; wherein the implant has an expanded configuration when deployed, the expanded implant having a region of maximum diameter that extends from a proximal portion of the distal region through the transition region and to a distal portion of the proximal region, wherein a diameter of a pore within the proximal portion of the distal region is larger than all pores in the distal portion of the proximal region; advancing the implant in the low profile radially constrained state within a microcatheter to a region of interest within a cerebral artery; deploying the implant within the cerebral aneurysm, wherein the distal and proximal permeable shells expand to their expanded shapes; and withdrawing the microcatheter from the region of interest after deploying the implant. ### Claim 12 (depends on 11) The method of claim 11, wherein the diameter of a pore in the proximal portion of the distal region is greater than 300 μm. ### Claim 13 (depends on 11) The method of claim 11, wherein the diameter of a pore in the proximal portion of the distal region is between about 300 μm and about 900 μm. ### Claim 14 (depends on 11) The method of claim 11, wherein the diameter of a pore in the proximal portion of the distal region is in a range selected from the group consisting of about 300 μm to about 900 μm, about 300 μm to about 700 μm, and about 300 μm to about 500 μm. ### Claim 15 (depends on 11) The method of claim 11, wherein the diameter of a pore in the distal portion of the proximal region is less than 200 μm. ### Claim 16 (depends on 11) The method of claim 11, wherein the diameter of a pore in the distal portion of the proximal region is between about 50 μm and about 200 μm. ### Claim 17 (depends on 11) The method of claim 11, wherein the diameter of a pore in the distal portion of the proximal region is in a range selected from the group consisting of about 50 μm to about 200 μm, about 50 μm to about 150 μm, and about 100 μm to about 200 μm ### Claim 18 (depends on 11) The method of claim 11, wherein the transition region is approximately 1000 μm high. ### Claim 19 (depends on 11) The method of claim 11, wherein the transition region has a height that is approximately about 0.5% to about 20% of a total height of the implant. ### Claim 20 (depends on 11) The method of claim 11, wherein the transition region has a height that is selected from the group consisting of approximately about 1% to about 15% of a total height of the implant, about 1% to about 10% of a total height of the implant, and about 3% to about 8% of a total height of the implant. ### Claim at position 21 21-181. (canceled)