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US 2016/0244729 A1Published application
Novel hcv culture systems and direct-acting antiviral sensitivity
AssigneeHvidovre Hospital
InventorsYiping Li, Santseharay Ramirez Almeida, Daryl Grant Humes, Judith M. Gottwein, Jens Bukh
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Abstract
The present invention relates to hepatitis C virus (HCV) culture systems of genotypes 1a, 3a, 4a, 5a, and 6a that directly contribute to HCV drug and vaccine development, to HCV basic research and better-individualized treatment of HCV infected patients.
Claims22
An isolated nucleic acid molecule, which encodes a human hepatitis C virus, wherein the hepatitis C virus comprises:
- a 5′UTR-NS5A region derived from the group consisting of genotype 1a strain H77, genotype 1a strain TN, genotype 3a strain S52, genotype 4a strain ED43, genotype 5a strain SA13, and genotype 6a strain HK6a, and
- further comprising the mutations F1464L in NS3 and A1672S in NS4A according to the H77 sequence (GenBank accession number AF009606).
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Dependencies are inferred from the claim text.