Opioid ketal compounds and uses thereof
AssigneeRhodes Technologies
InventorsRobert J. KUPPER, Raymond C. GLOWAKY
Life of this patent
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Abstract
This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.
Claims66
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is H or CH3,
- R2 is H or OH,
- n is 0, 1, 2 or 3,
- R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or
- when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form a five, six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl, and wherein the carbon atoms labeled * and ** are independently in the R or S configuration.
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13-17. (canceled)
19-22. (canceled)
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A compound of Formula II or Formula III:
- or a pharmaceutically acceptable salt thereof.
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36-42. (canceled)
A compound of Formula IV or Formula V:
- or a pharmaceutically acceptable salt thereof.
A mixture comprising at least two isomers selected from the group consisting of:
- and the pharmaceutically acceptable salts thereof.
A mixture comprising at least two isomers selected from the group consisting of
- and the pharmaceutically acceptable salts thereof.
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73-75. (canceled)
77-79. (canceled)
81-92. (canceled)
Dependencies are inferred from the claim text.