US 2016/0244451 A1Published application

Sulfonamide derivative and pharmaceutical use thereof

AssigneeAjinomoto Co., Inc.

InventorsHirokazu UENO, Takashi YAMAMOTO, Tomoko MIYAZAWA, Kenji SHINKAI, Harumi ARISAKA, Toshiyuki TAKANOHASHI

Life of this patent

Estimating the term…

Abstract

Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

Claims27

Dependent claims

A sulfonamide derivative represented by the general formula (1) below or a pharmaceutically acceptable salt thereof:

wherein
A represents a group represented by the general formula (2-1), (2-2), (2-3) or (2-4) below:
wherein
Arm is a cyclic alkyl group or an aromatic ring containing 0, 1, 2, 3, or 4 heteroatoms selected from oxygen atoms, sulfur atoms and nitrogen atoms,
R1, R11, R21, R51, and R52 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a lower alkylamino-lower alkyl group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkyl sulfonyl group, a sulfamoyl group, and an ammonium group,
R12, R13, and R14 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, a lower alkylamino-lower alkyl group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, and an ammonium group, and
R2, R3, R22, R23, R24, R25, and R53 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a lower alkylamino-lower alkyl group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, and an ammonium group,
B represents any one of an alkoxy group having 1 to 10 carbon atoms, a hydroxyl group, or a hydroxyamino group, these groups being optionally substituted with a substituent selected from the group consisting of an aryl group, a hydroxyl group, an alkyl group having 1 to 10 carbon atoms, a lower alkoxy group, a lower alkylamino group, a halogen atom, and a heterocyclic group,
R41 represents a hydrogen atom or a lower alkyl group,
a, b, c, and d independently represent C—R31, C—R32, C—R33, or C—R34, respectively, wherein one or two of a, b, c, and d may represent a nitrogen atom,
R31, R32, R33, and R34 each independently represent any one of a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, and a nitro group, wherein any one of R31, R32, R33, and R34 is a halogen atom or a lower alkyl group,
e, f, g, and h independently represent C—R35, C—R36, C—R37, or C—R38, respectively, wherein one or two of e, f, g, and h may represent a nitrogen atom,
R35, R36, R37, and R38 each independently represent any one of a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, and a nitro group,
D represents a phenyl group or a heterocyclic group, optionally having a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, and an ammonium group,
when A represents a group represented by the general formula (2-1), (2-2), or (2-3), E represents:
a 5- or 6-membered heterocyclic group substituted with a substituent selected from the group consisting of a 3- to 8-membered saturated ring group containing a nitrogen atom connected by a carbon atom, a 3- to 8-membered saturated or unsaturated ring group containing a heteroatom selected from an oxygen atom and a sulfur atom, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, a lower alkylamino group, and a lower alkenylamino group;
or a 5- or 6-membered cyclic ketone group containing 1 to 4 nitrogen atoms as atoms constituting the ring, the cyclic ketone group being substituted with a lower alkyl group or a lower alkenyl group, and
when A represents a group represented by the general formula (2-4), E represents:
a phenyl group or a 5- or 6-membered heterocyclic group optionally having a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a 3- to 8-membered saturated ring group containing a nitrogen atom connected by a carbon atom, a 3- to 8-membered saturated or unsaturated ring group containing a heteroatom selected from an oxygen atom and a sulfur atom, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, a lower alkylamino group, a lower alkenylamino group, a nitro group, a cyano group, an amino group, a 4- to 6-membered cyclic amino group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, and an ammonium group;
an aminocarbonyl group optionally having a substituent selected from the group consisting of a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkenyl group, an amino group, a lower alkylamino group, an aryl group, a heterocyclic group, a heterocyclic lower alkyl group, a lower alkylsulfonyl group, and a sulfamoyl group;
a hydrogen atom;
a halogen atom;
a hydroxyl group;
a lower alkyl group;
a lower alkenyl group;
a lower alkynyl group;
a lower alkoxy group;
a lower alkylthio group;
a hydroxy-lower alkyl group;
a hydroxy-lower alkenyl group;
a hydroxy-lower alkoxy group;
a halogeno-lower alkyl group;
a halogeno-lower alkoxy group;
a halogeno-lower alkylthio group;
a halogeno-lower alkenyl group;
a nitro group;
a cyano group;
an amino group;
a carboxyl group;
a dihydroxyboryl group;
a lower alkylcarbonyl group;
a lower alkyloxycarbonyl group;
a carbamoyl group;
a lower alkanoyl group;
an aroyl group;
a lower alkylsulfonyl group;
a sulfamoyl group;
an ammonium group;
a lower alkylaminoalkylene group;
or a 5- or 6-membered cyclic ketone group containing 1 to 4 nitrogen atoms as atoms constituting the ring, the cyclic ketone group being substituted with a lower alkyl group or a lower alkenyl group, wherein the lower alkylcarbonyl group and the lower alkyloxycarbonyl group may form a fused ring by being bonded to the phenyl group of D,
provided that the sulfonamide derivative excludes sulfonamide derivatives selected from the group consisting of (a) to (h) below:
(a) (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propanoic acid
(b) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propionate
(c) (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoic acid
(d) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoate
(e) (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propanoic acid
(f) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propanoate
(g) (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoic acid
and
(h) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoate

57 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/142,858Filed 29 Apr 2016
Priority: JP 2013-22469429 Oct 2013
Published: 25 Aug 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification26 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 9/00
Drugs for disorders of the cardiovascular system

Family

Application15/142,858Continuation
US 9,822,110 B2Related patent
US 2016/0244451 A1This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

patentgrep

Loading patent…

Abstract

A sulfonamide derivative represented by the general formula (1) below or a pharmaceutically acceptable salt thereof:

wherein
A represents a group represented by the general formula (2-1), (2-2), (2-3) or (2-4) below:
wherein
Arm is a cyclic alkyl group or an aromatic ring containing 0, 1, 2, 3, or 4 heteroatoms selected from oxygen atoms, sulfur atoms and nitrogen atoms,
R1, R11, R21, R51, and R52 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a lower alkylamino-lower alkyl group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkyl sulfonyl group, a sulfamoyl group, and an ammonium group,
R12, R13, and R14 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, a lower alkylamino-lower alkyl group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, and an ammonium group, and
R2, R3, R22, R23, R24, R25, and R53 each independently represent any one of a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a lower alkylamino group, a lower alkylamino-lower alkyl group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, and an ammonium group,
B represents any one of an alkoxy group having 1 to 10 carbon atoms, a hydroxyl group, or a hydroxyamino group, these groups being optionally substituted with a substituent selected from the group consisting of an aryl group, a hydroxyl group, an alkyl group having 1 to 10 carbon atoms, a lower alkoxy group, a lower alkylamino group, a halogen atom, and a heterocyclic group,
R41 represents a hydrogen atom or a lower alkyl group,
a, b, c, and d independently represent C—R31, C—R32, C—R33, or C—R34, respectively, wherein one or two of a, b, c, and d may represent a nitrogen atom,
R31, R32, R33, and R34 each independently represent any one of a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, and a nitro group, wherein any one of R31, R32, R33, and R34 is a halogen atom or a lower alkyl group,
e, f, g, and h independently represent C—R35, C—R36, C—R37, or C—R38, respectively, wherein one or two of e, f, g, and h may represent a nitrogen atom,
R35, R36, R37, and R38 each independently represent any one of a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, and a nitro group,
D represents a phenyl group or a heterocyclic group, optionally having a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a nitro group, a cyano group, an amino group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, and an ammonium group,
when A represents a group represented by the general formula (2-1), (2-2), or (2-3), E represents:
a 5- or 6-membered heterocyclic group substituted with a substituent selected from the group consisting of a 3- to 8-membered saturated ring group containing a nitrogen atom connected by a carbon atom, a 3- to 8-membered saturated or unsaturated ring group containing a heteroatom selected from an oxygen atom and a sulfur atom, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, a lower alkylamino group, and a lower alkenylamino group;
or a 5- or 6-membered cyclic ketone group containing 1 to 4 nitrogen atoms as atoms constituting the ring, the cyclic ketone group being substituted with a lower alkyl group or a lower alkenyl group, and
when A represents a group represented by the general formula (2-4), E represents:
a phenyl group or a 5- or 6-membered heterocyclic group optionally having a substituent selected from the group consisting of a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a lower alkylthio group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkylthio group, a halogeno-lower alkenyl group, a 3- to 8-membered saturated ring group containing a nitrogen atom connected by a carbon atom, a 3- to 8-membered saturated or unsaturated ring group containing a heteroatom selected from an oxygen atom and a sulfur atom, a lower alkoxy-lower alkylene group, a lower alkylthio-lower alkylene group, a lower alkylamino-lower alkylene group, a lower alkylamino group, a lower alkenylamino group, a nitro group, a cyano group, an amino group, a 4- to 6-membered cyclic amino group, a carboxyl group, a lower alkyloxycarbonyl group, a carbamoyl group, a lower alkanoyl group, an aroyl group, a lower alkylsulfonyl group, a sulfamoyl group, and an ammonium group;
an aminocarbonyl group optionally having a substituent selected from the group consisting of a hydroxyl group, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower alkoxy group, a hydroxy-lower alkyl group, a hydroxy-lower alkenyl group, a hydroxy-lower alkoxy group, a halogeno-lower alkyl group, a halogeno-lower alkoxy group, a halogeno-lower alkenyl group, an amino group, a lower alkylamino group, an aryl group, a heterocyclic group, a heterocyclic lower alkyl group, a lower alkylsulfonyl group, and a sulfamoyl group;
a hydrogen atom;
a halogen atom;
a hydroxyl group;
a lower alkyl group;
a lower alkenyl group;
a lower alkynyl group;
a lower alkoxy group;
a lower alkylthio group;
a hydroxy-lower alkyl group;
a hydroxy-lower alkenyl group;
a hydroxy-lower alkoxy group;
a halogeno-lower alkyl group;
a halogeno-lower alkoxy group;
a halogeno-lower alkylthio group;
a halogeno-lower alkenyl group;
a nitro group;
a cyano group;
an amino group;
a carboxyl group;
a dihydroxyboryl group;
a lower alkylcarbonyl group;
a lower alkyloxycarbonyl group;
a carbamoyl group;
a lower alkanoyl group;
an aroyl group;
a lower alkylsulfonyl group;
a sulfamoyl group;
an ammonium group;
a lower alkylaminoalkylene group;
or a 5- or 6-membered cyclic ketone group containing 1 to 4 nitrogen atoms as atoms constituting the ring, the cyclic ketone group being substituted with a lower alkyl group or a lower alkenyl group, wherein the lower alkylcarbonyl group and the lower alkyloxycarbonyl group may form a fused ring by being bonded to the phenyl group of D,
provided that the sulfonamide derivative excludes sulfonamide derivatives selected from the group consisting of (a) to (h) below:
(a) (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propanoic acid
(b) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propionate
(c) (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoic acid
(d) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-(2-tetrahydropyran-4-ylpyrimidin-5-yl)phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoate
(e) (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propanoic acid
(f) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[4-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)phenyl]propanoate
(g) (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoic acid
and
(h) cyclohexyl (2S)-2-[[2,5-difluoro-4-[[4-[2-(methoxymethyl)pyrimidin-5-yl]phenyl]sulfonylamino]benzoyl]amino]-3-[6-(1-methyl-2,4-dioxo-pyrido[3,4-d]pyrimidin-3-yl)-3-pyridyl]propanoate

57 more elements

Facts

Application

15/142,858Filed 29 Apr 2016

Priority

JP 2013-22469429 Oct 2013

Published

25 Aug 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification26 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 9/00
Drugs for disorders of the cardiovascular system