Expanded therapeutic potential in nitroheteroaryl antimicrobials

A compound having the structure of Formula (I)

• or pharmaceutically acceptable salts thereof, wherein
• J is N or CR3;
• is NR4, S, or O;
• R1 is hydrogen or —(CH2)m—Y—R5;
• R2 is hydrogen, —(CH2)m—Y—R5, —CH═CH—R5, —CHRa—CHRb—R5, —C═N—O—(CH2)m—R5, —NHC(O)—(CH2)m—R5, optionally substituted —S—C1-6 alkyl, optionally substituted —O—C1-6alkyl, optionally substituted C1-6alkyl, optionally substituted C2-10alkenyl, optionally substituted C2-10alkynyl, optionally substituted C3-10 cycloalkyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C6-10 aryl, or optionally substituted 5-10 membered heteroaryl;
• R3 is hydrogen, halogen, hydroxyl, or optionally substituted —C1-6 alkyl;
• R4 is hydrogen, C1-6alkyl or —(CH2)m—Y—R5;
• m is an integer between 0 to 5;
• Y is optionally substituted heteroaryl;
• each R5 is independently hydrogen, —(CH2)n-M, or —(CH2)n—Y′-M;
• each M is independently C(O)M′, —C(O)O—C1-4alkyl, —CH2-M′, —S-M′, —NHC(O)-M′, —NHC(O)NH-M′, —O—C6H4—C(O)NH-M′, —O-M′, —O(CH2)C(O)-M′, —N(CH3)-M′, optionally substituted —S—C1-6 alkyl, optionally substituted —O—C1-6alkyl, optionally substituted C1-6alkyl, optionally substituted C2-10alkenyl, optionally substituted C2-10 alkynyl, optionally substituted C3-10 cycloalkyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C6-10 aryl, or optionally substituted 5-13 membered heteroaryl;
• each M′ is independently hydrogen, optionally substituted C1-6alkyl, optionally substituted C2-10alkenyl, optionally substituted C2-10alkynyl, optionally substituted C3-10 cycloalkyl, optionally substituted 4-10 membered heterocyclyl, optionally substituted C6-10 aryl, or optionally substituted 5-13 membered heteroaryl;
• each Y′ is independently optionally substituted 4-10 membered heterocyclyl or C6-10 aryl;
• n is an integer between 0 to 5;
• Ra and Rb are each independently selected from —H, hydroxy, halogen, —C1-4alkyl, —O—C1-4alkyl, —O—C(O)—C1-4alkyl;
• with the proviso that the compound does not have the structure selected from the group consisting of