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US 2016/0244428 A1Published application
Efficient process for the preparation of esomeprazole (s)-binol complex
AssigneeF.I.S. Fabbrica Italiana Sintetici S.p.A.
InventorsPAOLO STABILE, MORENO BERTOLAZZI, NICOLA FACCIN, DIEGO RASIA
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Abstract
Object of the present invention is an improved process for the preparation of Esomeprazole (S)-BINOL complex which is a key intermediate for the synthesis of Esomeprazole and salts thereof.
Claims15
Process for the preparation of Esomeprazole (S)-(−)-BINOL complex of formula (I):
- comprising the following steps:
- A. providing a mixture of the optical isomers of the compound of formula (III):
- wherein the chiral center is on the sulfur atom, in dichloromethane;
- B. adding to the mixture of the step A from 0.8 to 3.0 molar equivalents of (S)-(−)-BINOL;
- C. adding an ethereal solvent containing from 5 to 10 atoms of carbon;
- D. stirring;
- E. isolating Esomeprazole (S)-(−)-BINOL complex of formula (I).
4 more elements
Dependencies are inferred from the claim text.