Chromene derivatives substituted by alkoxide as inhibitors of the tcr-nck interaction

A compound having the structure of formula (I)

• or a pharmaceutically acceptable salt, isomer or solvate thereof wherein:
• R1 is selected from hydrogen, substituted or not substituted C1-C6 alkyl, substituted or not substituted C3-C6 cycloalkyl, substituted or not substituted aryl or substituted or not substituted heteroaryl, —COR5, —C(O)OR5, —C(O)NR5R6, —CNR5,
• R2 and R3 are each independently selected from hydrogen, substituted or not substituted C1-C6 alkyl, substituted or not substituted C3-C6 cycloalkyl, substituted or not substituted aryl, substituted or not substituted heteroaryl, —COR7, —C(O)OR7, —C(O)NR7R8, —CNR7, —OR7, —NR7R8 and —NR7C(O)R8;
• or R2 and R3 form, together with the nitrogen atom they are bound to, a substituted or not substituted heterocycle;
• R4 is a halogen;
• R5, R6, R7 and R8 are each independently selected from hydrogen, C1-C4 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl and halogen
• with the proviso that the compound of formula (I) is not 1-(4-(4-fluorophenyl)-6-methoxy -2H-chromene-3-yl)methyl)pyrrolidine.