Substituted uracils as chymase inhibitors

A compound of the formula (I)

• in which
• R1 represents cyano, 5- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl,
• where 5- to 7-membered heterocyclyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of oxo, (C1-C4)-alkyl and halogen,
• and
• where 5- or 6-membered heteroaryl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C4)-alkyl, hydroxy and halogen,
• or
• R1 represents a group of the formula
• where
• * represents the point of attachment to the uracil group,
• m represents 0 or 1,
• L1A represents a bond or (C1-C4)-alkanediyl,
• in which (C1-C4)-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, hydroxy and (C1-C4)-alkoxy,
• R5 represents hydrogen or (C1-C4)-alkyl,
• R6 represents hydrogen or (C1-C4)-alkyl,
• in which (C1-C4)-alkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, hydroxy and (C1-C4)-alkoxy,
• or
• R5 and R6 together with the carbon atoms to which they are attached form a 3- to 7-membered carbocycle,
• R7 represents hydrogen, cyano, (C3-C7)-cycloalkyl, hydroxycarbonyl or (C1-C4)-alkoxycarbonyl,
• or
• R1 represents a group of the formula
• where
• *** represents the point of attachment to the uracil group,
• R2 represents a group of the formula
• where
• ** represents the point of attachment to the uracil nitrogen atom,
• A represents —CH2—, —CH2—CH2—, —O—CH2-## or oxygen,
• in which ## represents the point of attachment to the phenyl ring,
• n represents a number 0, 1 or 2,
• R10 represents hydrogen, halogen, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, difluoromethoxy, trifluoromethoxy or (C1-C4)-alkoxy,
• R11A represents hydrogen or deuterium,
• R11B represents hydrogen, deuterium or (C1-C4)-alkyl,
• R12 represents hydrogen, halogen, (C1-C4)-alkyl, difluoromethyl or trifluoromethyl,
• R13 represents halogen, (C1-C4)-alkyl, difluoromethyl or trifluoromethyl,
• R14 represents hydrogen or halogen,
• R15 represents hydrogen or halogen,
• R3 represents
• where
• # represents the point of attachment to the uracil nitrogen atom,
• R16 represents hydrogen,
• R17 represents hydrogen, halogen, (C1-C4)-alkyl or (C1-C4)-alkoxy,
• R18 represents (C1-C4)-alkyl, (C1-C4)-alkoxy, (C1-C4)-alkylthio, (C1-C4)-alkylsulfinyl, (C1-C4)-alkylsulfonyl or —N(R21R22),
• in which (C1-C4)-alkoxy may be substituted by a substituent independently of one another selected from the group consisting of hydroxy, (C1-C4)-alkoxycarbonyl, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino, aminocarbonyl, mono-(C1-C4)-alkylaminocarbonyl and di-(C1-C4)-alkylaminocarbonyl,
• where
• R21 represents (C1-C4)-alkyl, (C1-C4)-alkoxycarbonyl or (C1-C4)-alkylaminocarbonyl,
• in which (C1-C4)-alkylaminocarbonyl may be substituted by hydroxy or (C1-C4)-alkoxy,
• R22 represents hydrogen or (C1-C4)-alkyl,
• or
• R18 represents 4- to 7-membered heterocyclyl or 5- to 6-membered heteroaryl,
• in which 4- to 7-membered heterocyclyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, trifluoromethyl, (C1-C4)-alkyl, hydroxy, oxo, amino and (C1-C4)-alkoxycarbonyl,
• in which (C1-C4)-alkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of halogen, hydroxy and —N(R23R24),
• in which R23 represents hydrogen, (C1-C4)-alkyl or (C1-C4)-alkylcarbonyl,
• in which R24 represents hydrogen or (C1-C4)-alkyl,
• in which 5- to 6-membered heteroaryl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of halogen, trifluoromethyl, (C1-C4)-alkyl, hydroxy, amino and (C1-C4)-alkoxycarbonyl,
• in which (C1-C4)-alkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of halogen, hydroxy and —N(R23R24),
• in which R23 represents hydrogen, (C1-C4)-alkyl or (C1-C4)-alkylcarbonyl,
• in which R24 represents hydrogen or (C1-C4)-alkyl,
• R19 represents hydrogen, halogen, cyano, (C1-C4)-alkyl or (C1-C4)-alkoxy,
• R20 represents hydrogen, halogen, (C1-C4)-alkyl or (C1-C4)-alkoxy,
• or
• R3 represents
• in which
• # represents the point of attachment to the uracil nitrogen atom,
• the ring Q represents 5- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl,
• in which 5- to 7-membered heterocyclyl may be substituted by 1 to 4 substituents independently selected from the group of halogen, difluoromethyl, trifluoromethyl, trideuteromethyl, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, oxo, hydroxyl, (C1-C4)-alkylcarbonyl, (C1-C4)-alkoxycarbonyl, aminocarbonyl and (C1-C4)-alkylsulfonyl,
• in which 5- or 6-membered heteroaryl may be substituted by 1 to 2 substituents independently of one another selected from the group consisting of (C1-C6)-alkyl, (C3-C7)-cycloalkyl, hydroxy, (C1-C4)-alkylcarbonyl, (C1-C4)-alkoxycarbonyl, aminocarbonyl and (C1-C4)-alkylsulfonyl,
• and
• in which two (C1-C6)-alkyl radicals attached to a carbon atom of 5- to 7-membered heterocyclyl together with the carbon atom to which they are attached may form a 3- to 6-membered carbocycle,
• R25 represents halogen, (C1-C4)-alkyl or (C1-C4)-alkoxy,
• p represents a number 0, 1, 2 or 3,
• R4 represents hydrogen or (C1-C4)-alkyl,
• and the salts, solvates and solvates of the salts thereof.