Optical isomers of (+) and (-)-benzhydryl ureas and (+) and (-)-1-[(3-chlorophenyl)-phenyl-methyl] urea, a pharmaceutical composition based thereon and a method for producing said optical isomers

An optical isomers of (−)-1-[(3-chlorophenyl)-phenyl-methyl]urea represented by formula (I−) with negative rotation of the plane of polarization.

A method for the production of optical isomers of (+)- and (−)-1-[(3-chlorophenyl)-phenyl-methyl]urea in which a racemic mixture of benzhydrol amines represented by formula (II)

• where R≠R′, and selected from the group hydrogen and halogen found in the ortho-, para-, or meta-positions of benzene rings, are used to produce diastereomers of tartrates of benzhydrol amines represented by formula (II+)
• and formula (II−)
• in the presence of tartaric acids in an organic solvent, and optical isomers of (+)- and (−)-1-[(3-chlorophenyl)-phenyl-methyl]urea represented by the formulas (I+) and (I−) are obtained by the interaction of diastereomers of tartrates of benzhydrol amines represented by the formula (II+) and formula (II−) with cyanates of alkaline metals in an aqueous solution.