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US 2016/0243344 A1Published application
Cell encapsulation loading device
AssigneeJanssen Biotech, Inc.
InventorsStephen Evans, Audrey Bell
Life of this patent
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Abstract
The present invention provides a loading fixture for loading cells, cell clusters, and media to an immune-isolation device. The loading fixture permits the loading of cells into the immune-isolation device without manual manipulation of the immune-isolation device, until the loading device is opened at the point of use, thereby minimizing the risk of contamination of the immune-isolation device.
Claims47
A system for loading immune-isolation devices comprising:
- a base having a base bottom surface and a base wall extending from the base bottom surface to form a cavity;
- an inlet conduit positioned on the base and extending there through into the cavity of the base;
- a disk lid removably attachable to the base to seal the cavity;
- and
- a blade having an edge slidably disposed within the cavity of the base;
- wherein the edge of the blade is configured to slide in front of the inlet conduit;
- and
- wherein the system is configured to be vented.
5 more elements
A method of use of a loading device comprising,
- providing a loading device comprising,
- a base,
- a disk lid, having a luer adapter fixedly attached thereto,
- a snap lid, wherein the disk lid and snap lid form a cavity in the base,
- a blade ring assembly slidably connected to the base,
- a junction block fixedly attached to the base and having a luer adapter fixedly attached thereto,
- a barb, and a barb pusher slideably connected therein, and
- an immune-isolation device comprising an inlet tube and a cell pouch inserted within the cavity wherein the cell pouch rests on the base and the inlet tube is inserted through the junction block,
- sterilizing the loading device,
- filling the cell pouch with cells and the cavity with cell media,
- sealing the inlet tube with the barb,
- closing the loading device,
- transporting the loading device to the point of use,
- opening the loading device by rotating the disk lid counter-clockwise, thereby cutting the inlet tube, and
- removing the cell pouch from the loading device at the point of use.
12 more elements
A method of preparing immune-isolation devices, comprising:
- providing a loading system comprising:
- a base having a base bottom surface and a base wall extending from the base bottom surface to form a cavity,
- an inlet conduit positioned on the base and extending there through into the cavity, and
- a disk lid removably attachable to the base to seal the cavity;
- coupling an immune-isolation device comprising an inlet tube attached to a pouch, to the inlet conduit positioned on the base within the cavity;
- sealing the cavity with the disk lid;
- filling the pouch of the immune-isolation device with cells via the inlet conduit;
- filling the cavity with cell media;
- and
- sealing the inlet tube.
7 more elements
Dependencies are inferred from the claim text.