Dry powder drug delivery system and methods

A method of delivering of a dry powder using a high resistance dry powder inhaler comprising:

• a) providing a dry powder inhaler with an airflow resistance value ranging from about 0.065 (√kPa)/liter per minute to about 0.200 (√kPa)/liter per minute, the inhaler containing a dose of the dry powder within a movable container configured to move from a storage position to a dispensing position to form a flow path between one or more inlet ports and one or more dispensing ports within the inhaler,
• b) applying sufficient force to reach a peak inspiratory pressure of at least 2 kPa within 2 seconds;
• and
• c) generating an area under the curve in the first second (AUC0-1 sec) of a inspiratory pressure versus time curve of at least about 1.0, 1.1 or 1.2 kPa*sec;
• wherein greater than 75% of the dose of the dry powder is discharged or emitted from the inhaler as powder particles.