Radiopaque iodinated and iodide-containing crystalline absorbable aliphatic polymeric materials and applications thereof
OwnerShalaby W. Shalaby, Kenneth David Grayinventors
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Abstract
Radiopaque, iodinated, absorbable polyesters, polyester urethanes, and polyether-ester-urethanes with and without inorganic iodide micro-/nanoparticles dispersed or solubilized therein, and composite inorganic iodide micro-/nanoparticles in an absorbable polyester, polyester-urethane, polyester-ester, or polyether-ester urethane matrix are employed in medical devices and therapeutic compositions.
Claims14
1-21. (canceled)
A medical device comprising a radiopaque coating located on the medical device, the radiopaque coating comprising a radiopaque, iodinated, absorbable, crystalline, 80-100% aliphatic polymer.
A method of producing a radiopaque absorbable composite comprising:
- forming an organic absorbable crystalline matrix from a halogen-hydroxylic initiator and at least one cyclic monomer;
- dispersing a water soluble radiopaque halogen salt in the form of microparticles or nanoparticles into the organic absorbable crystalline matrix to provide a dispersion;
- and
- forming a radiopaque absorbable composite from the dispersion.
Dependencies are inferred from the claim text.