Tissue engineered devices and methods for making same
AssigneeThe Board of Regents of the University of Texas Sy Stem
InventorsScott Forrest COLLINS, Thomas BOLAND, Maria YANEZ
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Abstract
Tissue engineered constructs and methods for fabricating the disclosed constructs are provided. Some of the disclosed tissue engineered constructs are designed to fill a void in the body due to surgical resection, for example from mastectomy or lumpectomy, wounds and the like. Some disclosed constructs comprise one or more projections designed to mimic the appearance of a structural feature when implanted into a host.
Claims25
A volume forming unit (VFU) comprising adipocytes and at least one projection.
A method for creating a VFU, comprising:
- adding (i) a mixture comprising at least one biocompatible hydrogel material and a multiplicity of cells to (ii) a negative mold;
- incubating the mold under conditions suitable for hydrogel formation, thereby creating the VFU.
The method of 5, wherein the at least one biocompatible hydrogel material comprises at least one of fibrinogen, a fibrinogen activator, or thrombin.
A method for creating a multilayer tissue engineered construct, comprising:
- creating a multiplicity of construct layers, each comprising adipocytes, endothelial cells, or both;
- adhering at least one first construct layer in juxtaposition with at least one second construct layer to create a multilayer construct.
Dependencies are inferred from the claim text.