Hyaluronic acid and alginate hydrogel composition
AssigneeThe Regents of the University of California
InventorJonathan Kent LEACH
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Abstract
A hydrogel composition comprising an alginate polymer and a hyaluronic acid polymer is a useful polymer scaffold for mammalian tissue engineering. To enable cell adhesion, adhesion peptides may be covalently linked to a portion of the alginate and/or hyaluronic acid. This alginate-hyaluronic acid-adhesion peptide hydrogel composition localizes cells and other biological constituents to promote tissue repair at a site of tissue defect, while controlling the speed of gelation and resorption time.
Claims36
A hydrogel composition comprising an alginate polymer and a hyaluronic acid polymer, wherein a cell-instructive peptide is covalently linked to at least a portion of the alginate polymer or the hyaluronic acid polymer.
A hydrogel composition, comprising:
- an alginate polymer, the composition comprising 0.5%-5% alginate polymer;
- a hyaluronic acid polymer, the composition comprising 0.25%-5% hyaluronic acid polymer;
- and
- a mineralized polymeric microsphere,
- wherein a cell-instructive peptide is covalently linked to the alginate polymer and the hyaluronic acid polymer, and wherein the cell-instructive peptide is an adhesion peptide.
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Dependencies are inferred from the claim text.