Bioerodible silicon-based devices for delivery of therapeutic agents
AssigneeEyepoint Pharmaceuticas, Inc.
InventorsPaul ASHTON, Leigh T. Canham, Christian Barnett
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Abstract
This invention discloses bioerodible devices, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies, in a controlled manner. The devices comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The device may be used in vitro or in vivo to deliver the therapeutic agent, preferably in a controlled fashion over an intended period of time such as over multiple days, weeks or months. The device may be used for treating or preventing conditions of a patient such as chronic diseases.
Claims66
A device comprising a bioerodible porous silicon-based carrier material wherein the carrier material is impregnated with at least one large molecule therapeutic agent.
The device of any of the preceding claims, further comprising a second therapeutic agent impregnated in the carrier material.
A method of preparing a device of any of the preceding claims, comprising contacting a porous silicon-based carrier material with a therapeutic agent.
A composition comprising a bioerodible porous silicon-based carrier material, wherein the carrier material has at least two different populations of pores, wherein the differential between the average pore size of the at least two different populations of pores is at least about 5 nm.
A composition comprising a first plurality of bioerodible porous silicon-based particles having pores with a first average pore size and a second plurality of bioerodible porous silicon-based particles having pores with a second average pore size, wherein the first average pore size is at least 1.5 times the second average pore size.
A composition comprising a biomolecule loaded within the pores of a porous silicon-based carrier material, wherein the biomolecule within the carrier material has a half-life at room temperature that is at least twice the half-life of the biomolecule without the carrier material under the same conditions.
A composition comprising a biomolecule loaded within the pores of a porous silicon-based carrier material, wherein the biomolecule within the carrier material has a shelf life at room temperature that is at least twice as long as the shelf life of the biomolecule without the carrier material under the same conditions.
A syringe preloaded with a composition comprising a porous silicon-based carrier material, wherein the composition comprises less than 2% biomolecules.
A method of administering a therapeutic agent, comprising:
- a) providing a syringe preloaded with a porous silicon-based carrier material;
- b) contacting the carrier material with a therapeutic agent;
- and
- c) administering the carrier material to the patent.
A method for loading a protein into a pore of a porous silicon-based carrier material, comprising:
- selecting a porous silicon-based carrier having pore sizes dimensionally adapted to allow a single protein to load into the pore such that opposite sides of the protein engage opposite sides of the pore.
A method of controlled release delivery of a therapeutic agent, comprising:
- a) administering a bioerodible porous silicon-based carrier material to a patient;
- and
- b) administering a therapeutic agent to the same location of the body of the patient.
Dependencies are inferred from the claim text.