Polymer hydrogel adhesives formed with multiple crosslinking mechanisms at physiologic ph
AssigneeNorthwestern University
InventorsPhillip B. Messersmith, Devin G. Barrett, Iossif A. Strehin
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Abstract
The present invention encompasses biocompatible reactants, biocompatible product hydrogels, methods of use thereof, and methods of synthesis thereof using a novel crosslinking mechanism between a first reactant compound including an N-Hydroxysuccinimide (NHS) ester group and a second reactant compound including a N-terminal cysteine amine group. In certain embodiments, one or more of the reactant compounds may be a macromonomer.
Claims18
A hydrogel obtained by covalently cross-linking a first macromonomer comprising an N-Hydroxysuccinimide (NHS) ester group with a second macromonomer comprising a N-terminal cysteine group.
A method of synthesizing a hydrogel comprising covalently cross-linking an effective amount of a first macromonomer comprising an N-Hydroxysuccinimide (NHS) ester group with an effective amount of a second macromonomer comprising a N-terminal cysteine group, wherein a hydrogel is formed.
A kit for synthesizing a biocompatible hydrogel comprising:
- (a) a first macromonomer comprising an N-Hydroxysuccinimide (NHS) ester group;
- and
- (b) a second macromonomer comprising a N-terminal cysteine group.
Dependencies are inferred from the claim text.