Effects of Heparin on Topical Use of Plasters Containing a Non-Steroidal Anti-Inflammatory Drug
AssigneeAltergon S.A.
InventorsValeria Frangione, Arturo Lanzarotti
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Abstract
The present invention provides for a method of improving the release of non-steroidal anti-inflammatory drugs (NSAIDs) from a plaster or bandage comprising an adhesive layer with a pharmaceutically acceptable NSAID together with heparin or a heparinoid. The invention also provides for methods of reducing muscle hyperalgesia in subjects without spontaneous pain.
Claims10
Method of improving release of non-steroidal anti-inflammatory drugs (NSAIDs) from a bandage comprising:
- a) a substrate layer;
- b) an adhesive layer in the form of a polymeric hydrogel matrix comprising an effective amount of a pharmaceutically acceptable NSAID and heparin or a heparinoid, at least one thickening agent, at least one wetting agent, at least one cross-linking agent;
- and
- c) a protective film which can be removed at the moment of use, wherein said hydrogel matrix further comprises a surfactant consisting of sodium ethylenediamine tetraacetate;
- said method comprising
- topically applying said bandage to patients in need thereof;
- and
- assessing an improved NSAID release compared NSAID release from bandages without heparin.
Method of increasing membrane permeation of non-steroidal anti-inflammatory drugs (NSAID) from a bandage comprising:
- a) a substrate layer;
- b) an adhesive layer in the form of a polymeric hydrogel matrix comprising an effective amount of a pharmaceutically acceptable NSAID and heparin or a heparinoid, at least one thickening agent, at least one wetting agent, at least one cross-linking agent;
- and
- c) a protective film which can be removed at the moment of use, wherein said hydrogel matrix further comprises a surfactant consisting of sodium ethylenediamine tetraacetate;
- said method comprising:
- applying said bandage to a membrane;
- and
- assessing an increased membrane permeation of NSAID compared to membrane permeation obtainable from bandages without heparin.
Method of reducing muscle hyperalgesia in subjects without spontaneous pain, said method comprising:
- assessing an initial pain threshold in said subjects;
- applying to said subjects a bandage comprising:
- a) a substrate layer;
- b) an adhesive layer in the form of a polymeric hydrogel matrix comprising a pharmaceutically acceptable NSAID and heparin or a heparinoid, at least one thickening agent, at least one wetting agent, at least one cross-linking agent;
- and
- c) a protective film which can be removed at the moment of use, wherein said hydrogel matrix further comprises a surfactant consisting of sodium ethylenediamine tetraacetate;
- reassessing the pain threshold;
- and
- determining a reduced muscle hyperalgesia in said subjects measured as a difference between the initial and the reassessed pain threshold.
Dependencies are inferred from the claim text.