Labeled pkg-1-alpha-binding compounds and their use in imaging and quantifying pain
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAndrei O. Koren, Shi-Xian Deng, Donald W. Landry, Chaitanya R. Divgi
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Abstract
The present invention relates to the use of compounds that selectively bind to activated protein kinase G 1 alpha for imaging the anatomic basis for chronic pain. Such imaging may also be used to objectively quantify chronic pain.
Claims14
Radiolabeled NOP46.
A pharmaceutical composition comprising radiolabeled NOP46.
A method of identifying a dorsal root ganglion associated with pain in a subject, comprising administering, to the subject, a detectable amount of detectably labeled NOP compound, and then detecting labeled NOP compound that has localized in the dorsal root ganglion.
A method of quantifying the level of pain in a subject, comprising administering, to the subject, a detectable amount of detectably labeled NOP compound, and then quantifying the amount of labeled NOP compound that has localized in the dorsal root ganglion and/or comparing that level to a control value.
Dependencies are inferred from the claim text.