Pegylated nanoparticle compositions
AssigneeBOARD OFf REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
InventorsJie ZHENG, Jinbin LIU
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Abstract
An embodiment of the invention is directed to a composition comprising a noble metal nanoparticle, wherein the surface of the noble metal nanoparticle is coated with polyethylene glycol (PEG) having a size of 0.35 kDa to 5 kDa, and wherein the noble metal nanoparticle is about 2 nm to 10 nm in hydrodynamic diameter. In an embodiment of the invention, a therapeutic agent is also present on or in said nanoparticle.
Claims22
A composition comprising a labeled noble metal nanoparticle, wherein the surface of the noble metal nanoparticle is coated with polyethylene glycol (PEG) having a size of 0.35 kDa to 5 kDa, and wherein the noble metal nanoparticle is about 2 nm to 10 nm in hydrodynamic diameter.
20-30. (canceled)
A method for targeting a tumor cell comprising contacting the tumor cell an effective amount of a composition comprising noble metal nanoparticle, wherein the surface of the noble metal nanoparticle is coated with polyethylene glycol (PEG) having a size of 0.35 kDa to 5 kDa, and wherein the noble metal nanoparticle is about 2 nm to 10 nm in hydrodynamic diameter, and wherein conjugated with at least one therapeutic agent.
32-45. (canceled)
Dependencies are inferred from the claim text.