Compositions for Dermatological Use
AssigneeCipher Pharmaceuticals Inc.
InventorMorten SLOTH WEIDNER
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Abstract
The invention concerns novel compositions, and their use in the management of conditions associated with a defective or disrupted skin barrier in humans and animals. In particular, the invention relates to a colloid system resembling a cream with improved barrier properties. The invention may inter alia be used to diminish transepidermal water loss.
Claims46
A composition comprising:
- a) 15%-80% of an aqueous phase;
- b) 15%-80% of a lipid phase;
- d) 0.5%-2% of at least one unbranched alkylsulfate of C12-C20 or a salt thereof;
- e) 0.2%-2.0% of glyceryl monocaprylate;
- and optionally
- f) an antimicrobial preservative.
A composition comprising:
- a) Water;
- b) An emollient;
- d) An anionic water soluble emulsifier;
- and
- e) A lipid soluble emulsifier.
The composition according to any of the preceding claims, wherein the lipid phase comprises at least 5% high-melting lipids.
The composition according to any of the preceding claims, wherein said at least one unbranched alkylsulfate of C12-C20 or salt thereof is sodium cetostearyl sulphate.
The composition according to any of the preceding claims, comprising:
- a) Water;
- b) An emollient;
- c) A water soluble emulsifier;
- d) An anionic water soluble emulsifier;
- and
- e) A lipid soluble emulsifier.
The composition according to any of the preceding claims, comprising:
- a) 15%-65% water;
- b) 10%-60% of a branched or unbranched alkane of C12-C40;
- c) 5%-20% of at least one branched or unbranched alkanol of C14-C30;
- d) 0.5%-2% of at least one unbranched alkylsulfate of C12-C20 or a salt thereof;
- e) 0.2%-2.0% of glyceryl monocaprylate;
- and optionally
- f) an antimicrobial preservative.
The composition according to any of the proceeding claims further comprising:
- g) a humectant selected among glycerol and/or propylene glycol.
The composition according to any of the preceding claims, wherein the composition includes water in an intra-lipid and/or interstitial manner.
The composition according to any of the preceding claims, further comprising a bioactive ingredient.
A method for producing a composition, said method comprising:
- i. Mixing:
- a) Water;
- b) An emollient;
- c) A water soluble emulsifier;
- d) An anionic water soluble emulsifier;
- and
- e) A lipid soluble emulsifier;
- thereby allowing micelles to form in the mixture;
- and
- ii. Allowing at least part of the micelles in the mixture to merge, thereby obtaining homogenous particles, optionally by heating said mixture.
A composition comprising a colloid system, said system comprising a mixture of:
- a) Water;
- b) An emollient;
- c) A water soluble emulsifier;
- d) A anionic water soluble emulsifier;
- and
- e) A lipid soluble emulsifier, preferably an ingredient having HBL 5-6;
- Subject to the proviso that said mixture upon removal of water comprises homogenous particles and is substantially free of micelles.
Dependencies are inferred from the claim text.