Methods and compositions comprising a combination of a vegf antagonist and an anti-ctla-4 antibody
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsElla IOFFE, Israel LOWY, Gavin THURSTON, Elena BUROVA
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Abstract
The present invention provides pharmaceutical compositions comprising a VEGF antagonist and an anti-CTLA-4 antibody, and methods of use thereof. The compositions and methods of the present invention are useful for the treatment of cancers and other diseases and disorders in which anti-angiogenic therapies and/or targeted immune responses may be beneficial.
Claims25
1-9. (canceled)
A method for inhibiting or attenuating the growth of a tumor in a subject, the method comprising administering to the subject a therapeutically effective amount of a VEGF antagonist and a therapeutically effective amount of an anti-CTLA-4 antibody.
25-59. (canceled)
A method for inhibiting or attenuating the growth of a tumor in a subject, comprising:
- administering to the subject a therapeutically effective amount of a VEGF antagonist;
- and
- a therapeutically effective amount of an anti-CTLA-4 antibody, wherein the VEGF antagonist and the anti-CTLA-4 antibody are administered to the subject by injection.
Dependencies are inferred from the claim text.