Novel compositions and adjuvants
AssigneeID Biomedical Corporation of Quebec
InventorsMartin GAGNE, Daniel LAROCQUE, Martin PLANTE
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Abstract
The present invention is directed toward adjuvants that effect an innate and/or a specific immune response. The adjuvants contain at least one lipoprotein, such as Lip, Lip fragments or Lip variants, where the lipoprotein comprises at least one pentameric unit and at least one lipid moiety. Adjuvants wherein the lipoprotein make up at least 10% of the adjuvant by weight/volume are provided.
Claims12
An immunogenic composition comprising an adjuvant, said adjuvant comprising at least one lipoprotein comprising a lipid moiety and a polypeptide wherein the lipid moiety comprises at least one palmytoyl and the polypeptide is selected from the group of:
- SEQ ID NO:
- 9 and SEQ ID NO:
- 13.
An immunogenic composition consisting of Pam3Cys—GGEKAAEAPAAEAP (SEQ ID NO 9).
An immunogenic composition consisting of Pam3Cys-SQ EPAAPAAEAT PAAEAP (SEQ ID NO 13).
Dependencies are inferred from the claim text.