Compositions and methods for tolerizing cellular systems
AssigneeModerna Therapeutics, Inc.
InventorsStephen G. Hoge, Eric Yi-Chun Huang
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Abstract
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.
Claims19
A method of inducing tolerance in a cell system to an antigen comprising contacting said cellular system with a tolerogenic composition comprising the antigen and one or more polynucleotides.
A method of inducing Treg cell activity in a cellular system comprising contacting said system with a tolerogenic composition comprising an antigen and one or more polynucleotides.
A method of treating an autoimmune disease, inflammatory diseases, allograft transplant/graft vs. host disease (GVHD), diabetes or multiple sclerosis, comprising contacting a cell, tissue or organism with a tolerogenic composition comprising an antigen and one or more polynucleotides encoding a tolerogenic polypeptide of interest.
Dependencies are inferred from the claim text.