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US 2016/0243196 A1Published application
Methods of Using Interleukin-10 for Treating Diseases and Disorders
AssigneeArmo Biosciences, Inc.
InventorsJohn Brian Mumm, Ivan Ho Chan, Martin Oft
Life of this patent
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Abstract
Methods of treating subjects having diseases, disorders, or conditions, including cancer and immune- and inflammatory-related disorders, via the administration of IL-10 in combination with one or more additional agents, and methods and models associated therewith, are provided.
Claims44
A method of treating or preventing a disease, disorder or condition in a subject, comprising administering to the subject:
- a) a therapeutically effective amount of an inhibitor of at least one immune checkpoint, and
- b) a therapeutically effective amount of an IL-10 agent;
- and
- wherein the disease disorder or condition is a cancer or a cancer-related disease, disorder or condition.
1 more element
A method of treating or preventing a disease, disorder or condition in a subject, comprising administering to the subject:
- a) a therapeutically effective amount of an inhibitor of at least one immune checkpoint, and
- b) a therapeutically effective amount of an IL-10 agent, wherein the amount is sufficient to maintain a mean IL-10 serum trough concentration over a period of time;
- and
- wherein the mean IL-10 serum trough concentration is at least 1.0 ng/mL,
- wherein the mean IL-10 serum trough concentration is maintained for at least 90% of the period of time, and
- wherein the disease disorder or condition is a cancer or a cancer-related disease, disorder or condition.
3 more elements
Dependencies are inferred from the claim text.