Puma protein expression vector and use thereof in gene therapy
AssigneesHospices Civils De Lyon, The Regents of the University of California, Universite Claude Bernard Lyon 1, Institut d'Enseignement Superieur et de Recherche en Alimentation, Sante Animale, Sciences Agronomiq, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsPierre MIOSSEC, Saw-See HONG, Gary FIRESTEIN
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Abstract
The present invention relates to a viral vector for expression of the cell death-inducing PUMA protein, for use in gene therapy, for example for the treatment of rheumatoid arthritis. This vector consists in particular of a recombinant adenovirus expressing the gene encoding the PUMA protein and of a recombinant baculovirus containing a coxsackie-adenovirus receptor (CAR).
Claims9
A method of local treatment of a joint disease in a subject, comprising administering to the subject a complex consisting of (a) a recombinant adenovirus expressing the gene coding for the p53 up-regulated modulator of apoptosis (PUMA) protein under the control of a functional promoter in a mammal cell, and (b) a recombinant baculovirus containing a mammal coxsackie-adenovirus receptor (CAR) inserted into its envelope in an amount sufficient to induce apoptosis of synoviocytes in the subject.
Dependencies are inferred from the claim text.