Antibody dependent exosome therapy
AssigneeChildren's Hospital Los Angeles
InventorsRobert C. SEEGER, Muller FABBRI, Ambrose JONG, Alan S. WAYNE
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Abstract
Described herein are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof by administering an effective amount of a composition comprising exosomes that comprise Fc receptors. In some embodiments, the exosomes in the pharmaceutical compositions described herein comprise Fc receptors including Fcgamma1 (CD64), Fcgamma2 (CD32), Fcgamma3 (CD16) or combinations thereof.
Claims24
A pharmaceutical composition comprising exosomes comprising an Fc receptor and a pharmaceutically acceptable carrier.
The pharmaceutical composition of claim 15, further comprising one or more therapeutic agents, wherein the therapeutic agent is any one or more of lipids, peptides, proteins, antibodies, small molecules, oligonucleotides, nucleic acids or a combination thereof.
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A method for treating cancer in a subject in need thereof comprising:
- providing a composition comprising exosomes derived from cells, wherein the exosomes comprise Fc receptors;
- and
- administering an effective amount of the composition to the subject so as to treat cancer in the subject.
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24-27. (canceled)
Dependencies are inferred from the claim text.